COMPARISON IN WOMEN VERSUS MEN OF COMPOSITION OF ATHEROSCLEROTIC PLAQUES IN NATIVE CORONARY-ARTERIES AND IN SAPHENOUS VEINS USED AS AORTOCORONARY CONDUITS
COMPARISON IN WOMEN VERSUS MEN OF COMPOSITION OF ATHEROSCLEROTIC PLAQUES IN NATIVE CORONARY-ARTERIES AND IN SAPHENOUS VEINS USED AS AORTOCORONARY CONDUITS
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DOI：
10.1016/0735-1097(93)90302-h
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发表时间：
1993-05-01
影响因子：
24
通讯作者：
ROBERTS, WC
中科院分区：
文献类型：
--
作者：
MAUTNER, SL;LIN, FG;ROBERTS, WC
目标.本研究对女性与男性自体冠状动脉和用于冠状动脉搭桥术的隐静脉移植物中动脉粥样硬化斑块的成分进行了定量和比较。斑块成分在致死性冠状动脉疾病的各种表现和旁路手术后均有描述，但尚无报道按性别对斑块成分进行研究。应用计算机平面测量技术对11名女性和11名男性的979段5 mm冠状动脉和842段5 mm大隐静脉移植物进行了检查，这些患者在搭桥术后的生存时间相匹配。斑块成分的比较显示，与男性相比，女性的动脉粥样硬化斑块在天然冠状动脉（平均38% vs. 4%，p < 0.001）和隐静脉移植物（平均70% vs. 36%，p < 0.05）中含有更多的细胞纤维组织。相比之下，女性动脉粥样硬化斑块中致密纤维组织的比例显著低于男性，无论是在天然冠状动脉（平均50% vs. 85%，p < 0.001）还是在隐静脉移植物（平均25% vs. 57%，p < 0.05）。细胞纤维组织通常在斑块发展的早期阶段发现，而致密纤维组织是后期阶段的主要成分。因此，天然冠状动脉和隐静脉导管的斑块组成在男性和女性中不同，女性的斑块比男性的更年轻。
Objectives. This study quantifies and compares the components of atherosclerotic plaques in native coronary arteries and in saphenous vein grafts used for aortocoronary bypass surgery in women versus those in men.Background. Plaque composition has been described in various manifestations of fatal coronary artery disease and after the bypass operation, but no reports have investigated this composition according to gender.Methods. A total of 979 5-mm segments of native coronary arteries and 842 5-mm segments of saphenous vein grafts were examined by computerized planimetric technique in 11 women and 11 men who were matched for survival time after the bypass operation.Results. Comparison of the plaque components revealed that atherosclerotic plaques in women, compared with those in men, contained significantly more cellular fibrous tissue, both in native coronary arteries (mean 38% vs. 4%, p < 0.001) and in saphenous vein grafts (mean 70% vs. 36%, p < 0.05). In contrast, the proportion of dense fibrous tissue was significantly less in the atherosclerotic plaques of women than in those of men, both in native coronary arteries (mean 50% vs. 85%, p < 0.001) and in saphenous vein grafts (mean 25% vs. 57%, p < 0.05).Conclusions. Cellular fibrous tissue is often found at an early stage of plaque development, whereas dense fibrous tissue is a major component in later stages. Thus, the plaque composition of the native coronary arteries and saphenous venous conduits differed in men and women, with the plaques of the women appearing younger than those of the men.