Constitutive modelling of brain tissue: Experiment and theory
Constitutive modelling of brain tissue: Experiment and theory
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DOI：
10.1016/s0021-9290(97)00092-4
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发表时间：
1997-11-01
影响因子：
2.4
通讯作者：
Chinzei, K
中科院分区：
文献类型：
--
作者：
Miller, K;Chinzei, K
随着计算机集成和机器人辅助手术的发展，特别是自动手术工具和机器人的出现，以及虚拟现实技术的发展，要求对非常软的组织（如脑、肝、肾等）的力学特性进行更仔细的检查。我们研究这些组织的生物力学的最终目标是开发相应的，现实的数学模型。本文介绍了猪脑组织在体外单轴无侧限压缩的实验结果，并讨论了一个单相、非线性、粘弹性的组织模型。三个加载速度，范围超过五个数量级，得到的实验结果。所施加的应变率已远远低于在以前的研究中所应用的，专注于损伤建模。所有压缩率下的应力-应变曲线都是向上凹的，不含可以确定有意义的弹性模量的线性部分。随着加载速度的增加，组织反应变硬，表明强烈的应力-应变率依赖性。单相模型的使用，建议在注册，手术规划和培训系统，以及图像引导手术机器人的控制系统中的应用。计算了脑组织的材料常数。所提出的理论模型和实验之间的协议是好的压缩水平达到30%，加载速度变化超过五个数量级。(C)1997 Elsevier Science Ltd.保留所有权利。
Recent developments in computer-integrated and robot-aided surgery-in particular, the emergence of automatic surgical tools and robots-as well as advances in virtual reality techniques, call for closer examination of the mechanical properties of very soft tissues (such as brain, liver, kidney, etc.). The ultimate goal of our research into the biomechanics of these tissues is the development of corresponding, realistic mathematical models. This paper contains experimental results of in vitro, uniaxial, unconfined compression of swine brain tissue and discusses a single-phase, non-linear, viscoelastic tissue model. The experimental results obtained for three loading velocities, ranging over five orders of magnitude, are presented. The applied strain rates have been much lower than those applied in previous studies, focused on injury modelling. The stress-strain curves are concave upward for all compression rates containing no linear portion from which a meaningful elastic modulus might be determined. The tissue response stiffened as the loading speed increased, indicating a strong stress-strain rate dependence. The use of the single-phase model is recommended for applications in registration, surgical operation planning and training systems as well as a control system of an image-guided surgical robot. The material constants for the brain tissue are evaluated. Agreement between the proposed theoretical model and experiment is good for compression levels reaching 30% and for loading velocities varying over five orders of magnitude. (C) 1997 Elsevier Science Ltd. All rights reserved.