TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.
TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.
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DOI：
10.1158/0008-5472.can-11-1194
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发表时间：
2011-09-01
期刊：
影响因子：
11.2
通讯作者：
Mauviel A
中科院分区：
文献类型：
--
作者：
Javelaud D;Alexaki VI;Dennler S;Mohammad KS;Guise TA;Mauviel A
Hedgehog（Hh）和转化生长因子-β（TGF-β）信号通路代表胚胎发生期间细胞增殖和分化的重要调节因子。途径失调是各种癌症的特征。最近，已经出现了在肿瘤起始和进展至转移的背景下在GLI 2转录因子水平上这些途径的会聚的证据。这篇简短的综述总结了最近关于GLI 2功能和TGF-β在癌症中下游作用机制的知识。
The Hedgehog (Hh) and Transforming Growth Factor-β (TGF-β) signaling pathways represent essential regulators of cell proliferation and differentiation during embryogenesis. Pathway deregulation is a characteristic of various cancers. Recently, evidence for a convergence of these pathways at the level of the GLI2 transcription factor in the context of tumor initiation and progression to metastasis has emerged. This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer.