Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
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DOI：
10.1074/jbc.c600197200
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发表时间：
2006-09-29
影响因子：
4.8
通讯作者：
Andrews, Nancy C.
中科院分区：
文献类型：
--
作者：
Goswami, Tapasree;Andrews, Nancy C.
HFE 和转铁蛋白受体 2 (TFR2) 是哺乳动物铁稳态所必需的膜蛋白，并与人类遗传性血色素沉着症相关。在这里，我们证明 HFE 和 TFR2 在细胞中相互作用，这种相互作用不会因 HFE 和 TFR2 的疾病相关突变而消除，并且 TFR2 与 TFR1 竞争与 HFE 的结合。我们提出了一种铁状态传感机制的新模型，可调节铁稳态。
HFE and transferrin receptor 2 (TFR2) are membrane proteins integral to mammalian iron homeostasis and associated with human hereditary hemochromatosis. Here we demonstrate that HFE and TFR2 interact in cells, that this interaction is not abrogated by disease-associated mutations of HFE and TFR2, and that TFR2 competes with TFR1 for binding to HFE. We propose a new model for the mechanism of iron status sensing that results in the regulation of iron homeostasis.