[The research progress of relationship between advanced glycation end products and diabetic keratopathy].
[The research progress of relationship between advanced glycation end products and diabetic keratopathy].
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DOI：
10.3760/cma.j.issn.0412-4081.2018.06.018
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发表时间：
2018-06-11
期刊：
影响因子：
--
通讯作者：
Xie, L X
中科院分区：
文献类型：
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作者：
Dan, J;Zhou, Q J;Xie, L X
糖尿病性角膜病变是长期糖尿病患者常见的眼部并发症，对患者的视觉质量和视觉功能产生不良影响。一项研究报告糖尿病患者中糖尿病性角膜病变的发生率为47%至64%，但确切的潜在发病机制仍不清楚。有证据表明，晚期糖基化终末产物参与了糖尿病各种并发症的发生和发展，是高血糖记忆机制的关键因素。本文就糖基化终产物及其在角膜病变中的作用的研究现状和前景作一综述。(Chin J Ophthalmol，2018，54：475-480）。
Diabetic keratopathy is a common ocular complication of patients with a long-term history of diabetes and it will have a negative effect on the visual quality and function. A study reported that the incidence of diabetic keratopathy in diabetic patients ranged from 47% to 64%, but the precise underlying pathogenesis remains unclear. There is evidence that advanced glycation end products contribute substantially to the onset and progress of various diabetic complications and it is a key factor for the mechanism of the hyperglycemic memory. This review focuses primarily on the present research state and prospect of advanced glycation end products and their role in the pathological changes of the cornea. (Chin J Ophthalmol, 2018, 54: 475-480).