Anti-Mullerian hormone: a marker for oocyte quantity, oocyte quality and embryo quality?
Anti-Mullerian hormone: a marker for oocyte quantity, oocyte quality and embryo quality?
复制标题
DOI：
10.1016/s1472-6483(10)60480-4
复制
发表时间：
2008-05-01
影响因子：
4
通讯作者：
Laven, J. S. E.
中科院分区：
文献类型：
--
作者：
Fong, S. Lie;Baart, E. B.;Laven, J. S. E.
血清抗缪勒氏管激素（AMH）浓度随着年龄的增长而下降，是卵巢衰老的敏感标志。此外，基础血清 AMH 浓度可预测 IVF 周期期间的卵巢反应。与此同时，卵母细胞数量和胚胎质量随着年龄的增长而下降。因此，推测血清中的AMH构成胚胎质量的标志。月经周期规律、体重指数正常、精液参数正常的 37 岁及以下女性被随机分配接受标准或轻度刺激方案进行 IVF 治疗。在周期第 3 天和施用人绒毛膜促性腺激素当天抽取血样。使用胚胎形态评分和植入前遗传筛查来评估胚胎质量。周期第 3 天的血清 AMH 浓度与两组中取出的卵母细胞数量相关。 AMH 和胚胎形态在轻度刺激后相关，但在常规卵巢刺激后则不相关。 AMH 与胚胎染色体能力不相关。血清 AMH 可预测卵巢对刺激的反应。然而，胚胎形态和胚胎非整倍性率缺乏一致的相关性，不利于卵母细胞数量和胚胎质量之间的直接关系。
Serum anti-Mullerian hormone (AMH) concentrations decline with increasing age and constitute a Sensitive marker for ovarian ageing. In addition, basal serum AMH concentrations predict ovarian response during IVF cycles. Concomitantly, oocyte quantity and embryo quality decrease with advancing age. Hence, it was postulated that AMH in serum constitutes a marker for embryo quality. Women aged 37 years and younger with regular menstrual cycles, normal body mass index and partners with normal semen parameters were randomly assigned to either a standard or mild stimulation protocol for IVF treatment. Blood samples were drawn at cycle day 3 and at the day of human chorionic gonadotrophin administration. Embryo quality was assessed using embryo morphology score and preimplantation genetic screening. Serum AMH concentrations on cycle day 3 were correlated with the number of oocytes retrieved in both groups. AMH and embryo morphology were correlated after mild stimulation, but not after conventional ovarian stimulation. AMH and the chromosomal competence of embryos were not correlated. Serum AMH is predictive for ovarian response to stimulation. However, the lack of a consistent correlation with embryo morphology and embryo aneuploidy rate is not in favour of a direct relationship between oocyte quantity and embryo quality.