Falsely increased serum estradiol results reported in direct estradiol assays.

Falsely increased serum estradiol results reported in direct estradiol assays.
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DOI:
10.1093/clinchem/43.7.1250
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发表时间:
1997-07
期刊:
影响因子:
9.3
通讯作者:
Y. Leung;K. Dees;R. Cyr;I. Schloegel;P. Kao
Y. Leung;K. Dees;R. Cyr;I. Schloegel;P. Kao
中科院分区:
医学1区
文献类型:
--
作者:
Y. Leung;K. Dees;R. Cyr;I. Schloegel;P. Kao

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Direct, or nonextraction, assays of male sex hormones occasionally yield artefactually increased results (1)(2). Here, we report a patient who was determined by three direct assays to have an increased female sex hormone, estradiol, in serum. An 82-year-old man had a history of enlargement of the breast. Blood pressure was 110/86 mmHg. Erythrocyte and leukocyte counts were within the range of normal values. Results of thyroid-function tests were normal, and urea and creatinine concentrations in serum were within reference limits. Urinalysis results were also normal. Biopsy of breast tissue indicated gynecomastia. Computed tomographic scan showed normal adrenal glands, …