Blood lead concentration and delayed puberty in girls
Blood lead concentration and delayed puberty in girls
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DOI：
10.1056/nejmoa020880
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发表时间：
2003-04-17
影响因子：
158.5
通讯作者：
Bethel, J
中科院分区：
文献类型：
--
作者：
Selevan, SG;Rice, DC;Bethel, J
背景：环境铅暴露与生长和内分泌功能的改变有关。目前尚不清楚这种暴露是否会影响青春期发育。方法：我们分析了参加一项横断面研究(第三次全国健康和营养检查调查)的女孩(定义为8-18岁的女性)的血铅浓度与青春期发育的关系。在这项横断面研究中，种族自报或代理报告：600名非西班牙裔白人，805名非西班牙裔非裔美国人，781名墨西哥裔美国女孩。青春期根据初潮年龄和晒黑阶段的阴毛和乳房发育进行测量。结果：三组儿童的几何平均铅浓度均小于3微克/分升(0.144微克/升)。与每分升1微克的铅浓度(每升0.048微克)相比，每升3微克的铅浓度与身高下降有关(P
BACKGROUND:Environmental lead exposure has been linked to alterations in growth and endocrine function. It is not known whether such exposure affects pubertal development.METHODS:We analyzed the relations between blood lead concentration and pubertal development among girls (defined as females 8 to 18 years of age) who were enrolled in a cross-sectional study (the third National Health and Nutrition Examination Survey) in which race was self-reported or proxy-reported: 600 were non-Hispanic white, 805 were non-Hispanic African-American, and 781 were Mexican-American girls. Puberty was measured on the basis of the age at menarche and Tanner stage for pubic-hair and breast development.RESULTS:Geometric mean lead concentrations were less than 3 microg per deciliter (0.144 micromol per liter) in all three groups. As compared with concentrations of 1 microg per deciliter (0.048 micromol per liter), lead concentrations of 3 microg per deciliter were associated with decreased height (P