HYALURONAN AND TYPE-III PROCOLLAGEN PEPTIDE CONCENTRATIONS IN BRONCHOALVEOLAR LAVAGE FLUID IN IDIOPATHIC PULMONARY FIBROSIS
HYALURONAN AND TYPE-III PROCOLLAGEN PEPTIDE CONCENTRATIONS IN BRONCHOALVEOLAR LAVAGE FLUID IN IDIOPATHIC PULMONARY FIBROSIS
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DOI：
10.1136/thx.44.2.126
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发表时间：
1989-02-01
期刊：
影响因子：
10
通讯作者：
HALLGREN, R
中科院分区：
文献类型：
--
作者：
BJERMER, L;LUNDGREN, R;HALLGREN, R
对22例特发性肺纤维化患者和21例健康对照者的支气管肺泡灌洗液中结缔组织成分透明质酸（透明质酸）和III型前胶原肽进行测定。特发性肺纤维化患者具有比健康对照（9和< 0.2 μ g/l; p < 0.001）更高的透明质酸（中值46 μ g/l）和III型前胶原肽（中值0.45 μ g/l）浓度。患者血清中透明质酸和前胶原肽浓度正常，灌洗液中白蛋白浓度与对照组相似。特发性肺纤维化患者灌洗液中的中性粒细胞和淋巴细胞计数分别平均增加10倍和2倍，且均与回收的透明质酸量相关（p < 0.05）。一氧化碳转移因子与患者灌洗液中透明质酸浓度呈负相关（p < 0.05）。12例患者在6个月内观察到肺功能恶化和放射学进展。这些患者的灌洗液中透明质酸和III型前胶原肽的浓度高于疾病稳定的患者（p < 0.01）。肺实质中透明质酸和III型前胶原肽的合成增加可能反映了特发性肺纤维化中肺成纤维细胞的活化或增殖（或两者），似乎与肺部疾病的严重程度和活动有关。
The connective tissue components hyaluronan (hyaluronic acid) and type III procollagen peptide were measured in bronchoalveolar lavage fluid in 22 patients with idiopathic pulmonary fibrosis and 21 healthy control subjects. The patients with idiopathic pulmonary fibrosis had higher concentrations of hyaluronan (median 46 .mu.g/l) and type III procollagen peptide (median 0.45 .mu.g/l) than the healthy controls (9 and < 0.2 .mu.g/l; p < 0.001). The patients had normal serum concentrations of hyaluronan and of the procollagen peptide, and albumin concentrations in lavage fluid similar to those of the control subjects. Neutrophil and lymphocyte counts in lavage fluid were increased on average 10 and two fold respectively in the patients with idiopathic pulmonary fibrosis and both correlated with the amount of hyaluronan recovered (p < 0.05). An inverse correlation was seen between the transfer factor for carbon monoxide and hyaluronan concentrations in lavage fluid in the patients (p < 0.05). Deterioration in lung function and radiographic progression were seen over six months in 12 of the patients. These patients had higher lavage fluid concentrations of hyaluronan and type III procollagen peptide than the patients whose disease was stable (p < 0.01). Increased synthesis of hyaluronan and type III procollagen peptide in lung parenchyma may reflect activation or proliferation (or both) of pulmonary fibroblasts in idiopathic pulmonary fibrosis and seems to be linked to the severity and activity of the lung disease.