Temporal trends in prevalence of CKD: the glass is half full and not half empty.
Temporal trends in prevalence of CKD: the glass is half full and not half empty.
复制标题
CKD 患病率的时间趋势：杯子是半满的，而不是半空的。
DOI：
10.1053/j.ajkd.2013.05.003
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hsu,Chi-yuan
中科院分区：
文献类型：
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作者：
Hsu,RaymondK;Hsu,Chi-yuan
In this issue of AJKD, Grams et al1 report new information regarding the secular trend in chronic kidney disease (CKD) prevalence in the US population by comparing the prevalence of reduced cystatin C estimated glomerular filtration rate (eGFR) in 2 survey periods spanning more than a decade: NHANES III (Third National Health and Nutrition Examination Survey; 1988–1994) and NHANES 1999–2002. 1 Compared with prior studies (Table 1), this article’s novel contributions include the use of cystatin C as filtration marker after alignment of calibration in the 2 survey periods and use of the latest cystatin C GFR estimating equations. Grams et al1 found that the prevalence of eGFR< 60 mL/min/1.73 m2 in the United States increased significantly between those periods, from 5.5% to 8.7%, when cystatin C level was used to estimate GFR (eGFRcys) and from 4.4% to 7.1% when cystatin C and creatinine levels were used together to estimate GFR (eGFRcr-cys; both P< 0.001).Where does this article stand in the context of the prior literature? The first study to examine changes in the prevalence CKD in the United States over time systemically was by Hsu et al, 2 who analyzed data from NHANES II (1976–1980) and III (1998–1994). Hsu et al2 relied on the fact that for whites in both surveys who were aged 20–39 years and did not have diabetes or hypertension, median serum creatinine levels were 1.1 mg/dL in men and 0.9 mg/dL in women, which led them to conclude that there were no creatinine calibration differences. The authors found that in black and white adults aged 20–74 years, there was an increase in prevalence of stages 3–4 CKD from 2.0% to 2.5%. Stages 1 and 2 CKD could not be studied because proteinuria was not quantified in a consistent manner (NHANES II had only dipstick urinalysis).
