On carcinomas and other pathological entities.
On carcinomas and other pathological entities.
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DOI：
10.1002/cfg.497
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发表时间：
2005
影响因子：
--
通讯作者：
Rosse, Cornelius
中科院分区：
文献类型：
--
作者：
Smith, Barry;Kumar, Anand;Ceusters, Werner;Rosse, Cornelius
肿瘤、脓肿、囊肿、疤痕和骨折是我们所熟悉的病理性连续实体。这种类型的实例总是存在于解剖结构中或解剖结构上，从而转化为相应类型的病理解剖结构：胫骨骨折、拇指肿胀、结肠癌。在以前的生物医学本体论的工作中，我们展示了如何提供正式的定义关系，如is_a，part_of和transformation_of，可以促进这种本体论的集成方式，有可能支持新的自动推理。在这里，我们将这种方法扩展到病理学的治疗，特别是集中在器官受到癌症影响时出现的病理连续实体上。
Tumours, abscesses, cysts, scars and fractures are familiar types of what we shall call pathological continuant entities. The instances of such types exist always in or on anatomical structures, which thereby become transformed into pathological anatomical structures of corresponding types: a fractured tibia, a blistered thumb, a carcinomatous colon. In previous work on biomedical ontologies we showed how the provision of formal definitions for relations such as is_a, part_of and transformation_of can facilitate the integration of such ontologies in ways which have the potential to support new kinds of automated reasoning. We here extend this approach to the treatment of pathologies, focusing especially on those pathological continuant entities which arise when organs become affected by carcinomas.