Possible cooperation of differential adhesion and chemotaxis in mound formation of Dictyostelium
Possible cooperation of differential adhesion and chemotaxis in mound formation of Dictyostelium
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DOI：
10.1016/s0006-3495(98)77707-0
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发表时间：
1998-12-01
影响因子：
3.4
通讯作者：
Glazier, J
中科院分区：
文献类型：
--
作者：
Jiang, Y;Levine, H;Glazier, J
在盘基网柄菌的土丘阶段，前柄细胞排序并在顶端形成尖端。这种模式是如何形成的尚不清楚。细胞水平模型允许我们模拟差异细胞粘附和趋化性，以表明仅在差异粘附的情况下，前茎细胞移动到丘的表面但不形成尖端。通过仅由传出圆波驱动的趋化性，尖端形成但包含前茎细胞和前孢子细胞。仅当差异粘附和趋化性之间的相对强度范围较窄时，两种机制才能协同工作以形成仅包含前茎细胞的尖端。模拟提供了一种确定图案化所需过程的方法，并建议进行一系列进一步的实验。
In the mound stage of Dictyostelium discoideum, pre-stalk cells sort and form a tip at the apex. How this pattern forms is as yet unknown. A cellular level model allows us to simulate both differential cell adhesion and chemotaxis, to show that with differential adhesion only, pre-stalk cells move to the surface of the mound but form no tip. With chemotaxis driven by an outgoing circular wave only, a tip forms but contains both pre-stalk and pre-spore cells. Only for a narrow range of relative strengths between differential adhesion and chemotaxis can both mechanisms work in concert to form a tip containing only pre-stalk cells. The simulations provide a method to determine the processes necessary for patterning and suggest a series of further experiments.