Effects of ambient levels of air pollution generated by traffic on birth and placental weights in mice
Effects of ambient levels of air pollution generated by traffic on birth and placental weights in mice
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DOI：
10.1016/j.fertnstert.2007.10.001
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发表时间：
2008-11-01
影响因子：
6.7
通讯作者：
Saldiva, Paulo H. N.
中科院分区：
文献类型：
--
作者：
Rocha e Silva, Ingrid Ramos;Lichtenfels, Ana Julia F. C.;Saldiva, Paulo H. N.
目的：研究小鼠胎儿和/或胎盘重量与暴露于环境空气污染水平之间是否存在关联。设计：暴露于污染与清洁空气的小鼠慢性实验。设置：暴露于大气污染的环境。动物（S）：雌性Swiss小鼠（n = 70）在巴西一个大城市的交通繁忙的十字路口的暴露室中保持在不同的妊娠阶段。将对照小鼠保持在类似的室中，所述室位于暴露室附近，但配备有用于颗粒和反应性气体的过滤器。无暴露，整个妊娠期暴露于污染室，妊娠第1周暴露于污染室，第2和第3周暴露于污染室，在第1周和第2周暴露于污染舱，在第3周暴露于污染舱。主要结果测量（S）：在妊娠期结束时，在剖宫产后测定胎儿和胎盘重量。结果（S）：在怀孕第一周暴露于空气污染促进了胎儿体重的显着减少。小鼠暴露于污染的空气中，在妊娠的任何阶段，提出了较低的胎盘重量相比，小鼠保持在干净的chambers. Conclusions（S）：暴露于环境水平的交通污染在妊娠早期阶段是一个决定因素，最终胎儿体重下降。在妊娠的任何阶段暴露于空气污染都会降低胎盘重量。（Fertil Steril（R）2008;90：1921-4.（C）2008年由美国生殖医学协会。
Objective: To examine whether there is an association between fetal and/or placental weight and exposure to ambient levels of air pollution in mice.Design: Chronic experiments on mice that were exposed to polluted vs. clean air.Setting: Environmental exposure to atmospheric pollution.Animal(S): Female Swiss mice (n = 70) were maintained at different stages of gestation in an exposure chamber located at an intersection with heavy traffic in a major city in Brazil. Control mice were maintained in a similar chamber, located adjacent to the exposure chamber but equipped with filters for particles and reactive gases.Intervention(s): Animals were divided into six groups as follows: no exposure, exposure to a polluted chamber throughout gestation, exposure to a polluted chamber during the 1st week of pregnancy, exposure to a polluted chamber during the 2nd and 3rd weeks, exposure to a polluted chamber during the 1st and 2nd week, and exposure to a polluted chamber during the 3rd week.Main Outcome Measure(S): At the end of the gestational period, the determination of fetal and placental weight was performed after cesarean section.Result(s): Exposure to air pollution during the 1st week of pregnancy promoted a significant reduction in fetal weight. Mice exposed to polluted air, in any phase of gestation, presented with lower placental weight in comparison to mice maintained in clean chambers.Conclusion(s): Exposure to ambient levels of traffic pollution at early phases of gestation is a determinant for decreased final fetal weight. Placental weight is reduced with exposure to air pollution at any phase of gestation. (Fertil Steril (R) 2008;90:1921-4. (C)2008 by American Society for Reproductive Medicine.)