Early post-ischemic hyperemia on transcranial cerebral oxygen saturation monitoring in carotid endarterectomy is associated with severity of cerebral ischemic insult during carotid artery clamping
Early post-ischemic hyperemia on transcranial cerebral oxygen saturation monitoring in carotid endarterectomy is associated with severity of cerebral ischemic insult during carotid artery clamping
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DOI：
10.1179/174313209x382269
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发表时间：
2009-09-01
影响因子：
1.9
通讯作者：
Ogawa, Akira
中科院分区：
文献类型：
--
作者：
Kobayashi, Masakazu;Ogasawara, Kuniaki;Ogawa, Akira
背景与目的：在动物模型中，早期缺血后充血的程度往往与先前缺血损伤的持续时间和强度相关。本研究的目的是确定颈动脉内膜切除术（CEA）过程中早期脑缺血充血是否与颈内动脉夹持（ICA）过程中脑缺血损伤的严重程度有关。方法：采用近红外光谱法监测171例同侧ICA狭窄患者术中经颅脑氧饱和度，评估ICA夹持期间大脑半球缺血程度及ICA去夹持后早期缺血充血程度。结果：早期缺血后充血在ICA去支后3分钟内达到高峰，在ICA去支后20分钟消退。早期缺血后充血程度与脑缺血程度呈显著相关（r=0.697; p . 698）
Background and objective: In animal models, the magnitude of early post-ischemic hyperemia tends to correlate with the duration and intensity of prior ischemic insult. The aim of this study was to determine whether early post-ischemic hyperemia in human brain during carotid endarterectomy (CEA) is associated with the severity of cerebral ischemic insult during clamping of the internal carotid artery (ICA).Methods: Transcranial cerebral oxygen saturation using near-infrared spectroscopy was monitored intraoperatively in 171 patients undergoing CEA for ipsilateral ICA stenosis (>70%) to assess the intensity of cerebral hemispheric ischemia during ICA clamping and the magnitude of early post-ischemic hyperemia after ICA declamping.Results: Early post-ischemic hyperemia peaked within 3 minutes after ICA declamping and resolved at 20 minutes after ICA declamping. A significant correlation was observed between the magnitude of early post-ischemic hyperemia and the intensity of cerebral ischemia (r=0.697; p