Oxidative Stress Response After Laparoscopic Versus Conventional Sigmoid Resection: A Randomized, Double-blind Clinical Trial
Oxidative Stress Response After Laparoscopic Versus Conventional Sigmoid Resection: A Randomized, Double-blind Clinical Trial
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腹腔镜与传统乙状结肠切除术后的氧化应激反应：随机、双盲临床试验
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
I. Gögenur
中科院分区：
文献类型：
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作者：
M. T. Madsen;B. Kücükakin;J. Lykkesfeldt;J. Rosenberg;I. Gögenur
手术伴随着手术应激反应，导致发病率和死亡率增加。氧化应激是手术应激反应的一部分。微创腹腔镜手术可能会导致减少氧化应激相比，开放手术。在一项双盲、前瞻性临床试验中，19例计划行乙状结肠切除术的患者被随机分配至开放式或腹腔镜乙状结肠切除术组。在6个不同的时间点（术前、术后1 h、6 h、24 h、48 h和72 h）测定氧化应激的3种生化标志物（丙二醛、抗坏血酸和脱氢抗坏血酸）。腹腔镜手术和开放手术的3个氧化应激参数均无统计学显著差异。19例患者术后1小时丙二醛均降低（P<0.001）。所有19名患者在第一次腹部切口后1小时和6小时的抗坏血酸水平均显著下降（P=0.002）。腹腔镜手术与氧化应激降低无关。
Surgery is accompanied by a surgical stress response, which results in increased morbidity and mortality. Oxidative stress is a part of the surgical stress response. Minimally invasive laparoscopic surgery may result in reduced oxidative stress compared with open surgery. Nineteen patients scheduled for sigmoid resection were randomly allocated to open or laparoscopic sigmoid resection in a double-blind, prospective clinical trial. Three biochemical markers of oxidative stress (malondialdehyde, ascorbic acid, and dehydroascorbic acid) were measured at 6 different time points (preoperatively, 1 h, 6 h, 24 h, 48 h, and 72 h postoperatively). There were no statistical significant differences between laparoscopic and open surgery for any of the 3 oxidative stress parameters. Malondialdehyde was reduced 1 hour postoperatively (P<0.001) for all 19 patients. There was a significant drop in ascorbic acid at 1 hour and 6 hours after the first abdominal incision (P=0.002) for all 19 patients. Laparoscopic surgery was not found to be associated with reduced oxidative stress.
影响因子：
7.4
作者：
Christen, S;Finckh, B;Schmitt, B
通讯作者：
Schmitt, B