Does the clinical use of ethanol-based hand sanitizer elevate blood alcohol levels? A prospective study
Does the clinical use of ethanol-based hand sanitizer elevate blood alcohol levels? A prospective study
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DOI：
10.1016/j.ajem.2006.05.006
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发表时间：
2006-11-01
影响因子：
3.6
通讯作者：
Crystal, Chad S.
中科院分区：
文献类型：
--
作者：
Miller, Michael A.;Rosin, Alex;Crystal, Chad S.
背景：以乙醇为基础的洗手液(EBHS)在美国大多数医疗机构中都有使用。感染控制人员主张在与患者接触之前和之后大量使用EBHS。虽然假设在EBHS使用过程中乙醇几乎不会发生全身吸收，但许多酒精通过透皮途径被不同程度地吸收。医疗工作场所员工酒精中毒是一种潜在的严重发现，阐明频繁使用EBHS对血清乙醇水平(BELS)的影响具有法医学和医学法律意义。为了研究频繁使用EBHS对血清乙醇浓度的影响，我们对5名经常使用EBHS的志愿者进行了前瞻性研究。方法：受试者将该产品(62%变性酒精，由金伯利C LLAK，Roswell，GA)涂抹在双手上，揉至干燥。这一活动在4小时内重复了50次。参与者在完成研究之前和完成研究后都进行了抽血。每个参与者在研究前12小时内没有饮酒。结果：5名志愿者入选。所有患者的初始血液酒精水平均低于5 mg/dL。所有5名参与者都完成了这项4小时的研究。在研究期间没有发现明显的不良反应。在完成50次EBHS应用后，所有5名研究参与者的血液酒精水平均低于5 mg/dL。结论：本研究结果表明，根据标签频繁使用乙醇基洗手液，不会提高血清乙醇水平。(C)2006 Elsevier Inc.保留所有权利。
Background: Ethanol-based hand sanitizers (EBHSs) are used in most health care facilities in the United States. Infection control personnel advocate the use of generous quantities of EBHS before and after contact with patients. Although it is assumed that little systemic absorption of ethanol occurs during EBHS use, many alcohols are absorbed to varying degrees via the transdermal route. Ethanol intoxication by employees in the medical workplace is a potentially serious finding, and it is of forensic and medical-legal importance to elucidate the effects of frequent use of EBHS upon serum blood ethanol levels (BELs). To investigate the effect of frequent use of EBHS upon serum blood ethanol concentrations, we prospectively studied 5 volunteers undergoing frequent application of EBHS.Methods: Enrolled subjects applied 5 mL of the product (62% denatured ethyl alcohol manufactured by Kimberley-C lark, Roswell, GA) to both hands and rubbed until dry. This activity was repeated 50 times over 4 hours. Participants had their blood drawn before as well as after completing the study. Each participant was without alcohol exposure during the 12 hours preceding the study.Results: Five volunteers were enrolled. All had an initial blood ethanol level of less than 5 mg/dL. All 5 participants completed the 4-hour study. There were no noted adverse reactions during the study. Blood ethanol level upon completion of the 50 applications of EBHS was less than 5 mg/dL in all 5 study participants.Conclusion: The results of this study demonstrate that use of ethanol-based hand sanitizers, when frequently used in accordance with labeling, do not raise serum blood ethanol levels. (C) 2006 Elsevier Inc. All rights reserved.