Hepatitis C virus infection in patients with oral lichen planus
Hepatitis C virus infection in patients with oral lichen planus
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DOI：
10.4103/1119-3077.84025
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发表时间：
2011-04-01
影响因子：
0.9
通讯作者：
Pavani, B. V.
中科院分区：
文献类型：
--
作者：
Konidena, A.;Pavani, B. V.
背景：扁平苔藓（Lichen planus， LP）是一种病因不明的慢性皮肤粘膜疾病。最近的报道表明LP是丙型肝炎感染的肝外表现。目的：探讨丙型肝炎病毒（HCV）感染与口腔LP的关系，探讨口腔LP患者的肝功能指标。研究设计：对25例口服LP患者和同等数量的对照组进行横断面病例-对照研究。该研究在2008年1月至6月间在一所牙科学院的门诊部进行了为期6个月的研究。采用逆转录引物聚合酶链反应和肝功能（胆红素、转氨酶和碱性磷酸酶）检测患者和对照组血清中的HCV核糖核酸（RNA）。结果：25例LP患者中，3例（12%）有HCV感染。对照组无HCV RNA阳性（P = 0.2347）。口腔LP患者血清胆红素和转氨酶高于对照组（P < 0.05）。而碱性磷酸酶无显著性差异。hcv阳性和阴性患者的肝功能检查无显著差异。结论：口腔LP患者中HCV感染率增加。我们的发现支持这两种疾病之间可能的病因学关联。
Background: Lichen planus (LP) is a chronic mucocutaneous disease of uncertain etiology. Recent reports suggest that LP is an extrahepatic manifestation of Hepatitis C infection.Objective: To determine the association of Hepatitis C virus (HCV) infection with oral LP and to study the tests of liver function in patients with oral LP.Study Design: A cross-sectional case-control study was carried out on 25 patients with oral LP and an equal number of controls. The study was conducted in the outpatient department of a dental college for a period of six months between January and June 2008. The sera of the patients and controls were tested for HCV ribonucleic acid (RNA) using reverse transcription primed-polymerase chain reaction and liver function tests (bilirubin, transaminases, and alkaline phosphatase).Results: Of the 25 patients with LP, three (12%) had HCV infection. None of the controls had HCV RNA positivity (P = 0.2347). Oral LP patients had higher serum bilirubin and transaminases when compared with controls (P < 0.05). However, there was no significant difference in alkaline phosphatase. HCV-positive and -negative patients did not differ significantly in liver function tests.Conclusions: An increased prevalence of HCV infection was seen in oral LP patients. Our findings support a possible etiological association between these two diseases.