Evaluation of the Pharmaceutical Properties and Value of Astragali Radix.
Evaluation of the Pharmaceutical Properties and Value of Astragali Radix.
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DOI：
10.3390/medicines5020046
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发表时间：
2018-05-21
期刊：
影响因子：
--
通讯作者：
Chan K
中科院分区：
文献类型：
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作者：
Gong AGW;Duan R;Wang HY;Kong XP;Dong TTX;Tsim KWK;Chan K
黄芪（AR）是一种中药（CMM），被称为黄芪，是数千年来中医（TCM）从业者在中药复方（复方）中处方的重要药物。据文献报道，AR适合气血两虚的患者，据报道其临床效果与抗癌细胞增殖、抗氧化、缓解心血管疾病并发症等有关。本文介绍了参与调节这些不同疾病的潜在细胞信号通路，以支持AR的作用机制。 《中国药典》（CP，2015 年版）收载了两种植物来源：黄芪 (Astragalus membranaceus (Fisch.) Bge)。变种。 mongohlicus、(Bge.) Hsiao 和黄芪 (Fisch.) Bge。 （豆科植物），其干燥根提取物通过均质辅助负压空化萃取进行处理。地理因素和提取方法对 AR 的药物和化学特性有影响。因此，不同批次提取物中AR的主要生物活性成分（包括多糖、皂苷和黄酮类化合物）的含量可能不一致，并且这些生物活性成分的药效可能因来源而异。因此，本综述主要集中在AR和提取物的可用来源的一致性以及AR及其主要生物活性成分的生物学功能和作用机制的研究上。此外，还将讨论最流行的 AR 复合配方，以进一步阐明其化学和生物学特征并了解 AR 的制药价值。
Astragali Radix (AR), a Chinese materia medica (CMM) known as Huangqi, is an important medicine prescribed in herbal composite formulae (Fufang) by Traditional Chinese medicine (TCM) practitioners for thousands of years. According to the literature, AR is suggested for patients suffering from “Qi”- and “Blood”-deficiencies, and its clinical effects are reported to be related to anti-cancer cell proliferation, anti-oxidation, relief of complications in cardiovascular diseases, etc. The underlying cell signaling pathways involved in the regulation of these various diseases are presented here to support the mechanisms of action of AR. There are two botanical sources recorded in China Pharmacopoeia (CP, 2015): Astragalus membranaceus (Fisch.) Bge. Var. mongohlicus, (Bge.) Hsiao, and Astragalus membranaceus (Fisch.) Bge. (Fam. Leguminosae), whose extracts of dried roots are processed via homogenization-assisted negative pressure cavitation extraction. Geographic factors and extraction methods have impacts on the pharmaceutical and chemical profiles of AR. Therefore, the levels of the major bioactive constituents of AR, including polysaccharides, saponins, and flavonoids, may not be consistent in different batches of extract, and the pharmaceutical efficacy of these bioactive ingredients may vary depending on the source. Therefore, the present review mainly focuses on the consistency of the available sources of AR and extracts and on the investigation of the biological functions and mechanisms of action of AR and of its major bioactive constituents. Furthermore, it will also include a discussion of the most popular AR composite formulae to further elucidate their chemical and biological profiles and understand the pharmaceutical value of AR.