How Does Water Diffusion in Human White Matter Change Following Ischemic Stroke?
How Does Water Diffusion in Human White Matter Change Following Ischemic Stroke?
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DOI：
10.2463/mrms.8.121
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发表时间：
2009-01-01
影响因子：
3
通讯作者：
Shimosegawa, Eku
中科院分区：
文献类型：
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作者：
Tamura, Hajime;Kurihara, Noriko;Shimosegawa, Eku
目的：水表观扩散系数（ADC）的时间演变平行（ADC平行于）和垂直（ADC）的人白色束缺血后尚未进行系统的研究。我们试图量化ADC平行和ADC垂直的演变，并检查它是否可以解释的缺血性edema.Methods模型：我们回顾性地选择了53例缺血性病变涉及后肢的内囊（PLIC）和放置在ADC地图上的权利和左侧PLIC的兴趣区域。我们对病变与对侧ADC平行和ADC垂直的比值与发病时间（t=1-1600 h）进行回归分析。然后，我们拟合的ADC平行和ADC垂直于从分析中获得的神经组织的模型组成的圆柱体（轴突）和球体对应的各向同性结构，特别是局灶性的胶质细胞和轴突的细胞质selling缺血白色matter.Results的ADC的演变垂直和ADC平行于不同。ADC的估计时间过程平行于μ m（2）。ms（-1）为0.64 ± 0.88exp（-0.24t）（1 < t < 54 h）和0.00059t ± 0.61（54 h）（对侧正常值1.52）。垂直于ADC值1 < t < 54 h为0.19 - 0.063 exp（-0.24t），t >= 54 h为0.00040 t + 0.17（正常值0.22）。模型拟合这些值表明，圆柱体的体积减少，增加的球体，和细胞外体积变化不大，从一个小时到大约一天后中风onset.Conclusion：在人类PLIC，ADC平行于继续减少，从中风发作后1小时到几天，和ADC垂直于增加的趋势。时间的演变可以解释的进展，以前在动物研究中观察到的神经胶质细胞和轴突的局灶性细胞质肿胀。
Purpose: Temporal evolution of the water apparent diffusion coefficients (ADC) parallel (ADC parallel to) and perpendicular (ADC) to the human white matter tract following ischemia has not been investigated systematically. We attempted to quantify the evolution of ADC parallel to and ADC perpendicular to and examine whether it can be interpreted by a model of ischemic edema.Methods: We retrospectively selected 53 patients with ischemic lesions involving the posterior limb of the internal capsule (PLIC) and placed regions of interest in the right and left PLIC on ADC maps. We performed regression analysis of lesion-to-contralateral ratios of ADC parallel to and ADC perpendicular to against the time (t=1-1600 h) from onset. We then fitted the estimated time courses of ADC parallel to and ADC perpendicular to obtained from the analysis to a model of nerve tissue composed of cylinders (axons) and spheres corresponding to isotropic structures, particularly focal cytoplasmic swellings of glial cells and axons seen in ischemic white matter.Results: The evolution of ADC perpendicular to and ADC parallel to differed. The estimated time course of ADC parallel to in mu m(2) . ms(-1) was 0.64 + 0.88 exp (-0.24t) for 1 < t < 54 h and 0.00059t + 0.61 for 54 h (contralateral normal value, 1.52). That of ADC perpendicular to was 0.19 - 0.063 exp (-0.24t) for 1 < t < 54 h and 0.00040t + 0.17 for t >= 54 h (normal value 0.22). The model fitted to these values showed that the volume of the cylinders decreased, that of the spheres increased, and extracellular volume changed little from one hour to approximately one day after stroke onset.Conclusion: In the human PLIC, ADC parallel to continued to decrease from one hour to a few days after stroke onset, and ADC perpendicular to tended to increase. The temporal evolution could be interpreted by progression of the focal cytoplasmic swelling of glial cells and axons previously observed in animal studies.