Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia.
Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia.
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单词的语义和词汇特征受到不流利、语词减少和语义原发性进行性失语症的影响不同。
DOI：
10.1017/s1355617719000948
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Obler,LoraineK
中科院分区：
文献类型：
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作者：
Vonk,JetMJ;Jonkers,Roel;Hubbard,HIsabel;Gorno-Tempini,MariaLuisa;Brickman,AdamM;Obler,LoraineK
目的探讨非流利型（nfvPPA）、逻辑缺失型（lvPPA）和语义原发性进行性失语（svPPA）患者的词汇-语义加工过程中，词频、习得年龄（AoA）和邻域密度（ND）3个心理语言学变量的作用。识别这些特征的范围和独立性可以提供有关单词在我们的头脑和大脑中的组织的有价值的信息。方法我们对41名PPA患者进行了一项词汇决策任务-仔细选择单词以区分词频，AoA和正字法ND效应结果在所研究的心理语言学变量中，词频对词汇语义加工的影响最大，但AoA和ND也起着独立的作用。结果反映了大脑语言的关系与不同的比例影响的频率，AoA，和ND在PPA的变种，在一个模式，是一致的组织的心理词汇。与nfvPPA和lvPPA的个人经历了ND效应一致的下额叶和颞顶区的作用，在词汇分析和词形处理。相比之下，svPPA个体经历了与前颞叶在语义加工中的作用一致的AoA效应。（语义）和一个词位（词形）水平，这样，在这些水平的心理词汇之一的选择性缺陷表现不同的词汇语义处理性能，与每个PPA变体中受影响的语言特异性大脑区域一致。
ObjectiveTo determine the effect of three psycholinguistic variables—lexical frequency, age of acquisition (AoA), and neighborhood density (ND)—on lexical-semantic processing in individuals with non-fluent (nfvPPA), logopenic (lvPPA), and semantic primary progressive aphasia (svPPA). Identifying the scope and independence of these features can provide valuable information about the organization of words in our mind and brain.MethodWe administered a lexical decision task—with words carefully selected to permit distinguishing lexical frequency, AoA, and orthographic ND effects—to 41 individuals with PPA (13 nfvPPA, 14 lvPPA, 14 svPPA) and 25 controls.ResultsOf the psycholinguistic variables studied, lexical frequency had the largest influence on lexical-semantic processing, but AoA and ND also played an independent role. The results reflect a brain-language relationship with different proportional effects of frequency, AoA, and ND in the PPA variants, in a pattern that is consistent with the organization of the mental lexicon. Individuals with nfvPPA and lvPPA experienced an ND effect consistent with the role of inferior frontal and temporoparietal regions in lexical analysis and word form processing. By contrast, individuals with svPPA experienced an AoA effect consistent with the role of the anterior temporal lobe in semantic processing.ConclusionsThe findings are in line with a hierarchical mental lexicon structure with a conceptual (semantic) and a lexeme (word-form) level, such that a selective deficit at one of these levels of the mental lexicon manifests differently in lexical-semantic processing performance, consistent with the affected language-specific brain region in each PPA variant.