Myalgia as a symptom at hospital admission by severe acute respiratory syndrome coronavirus 2 infection is associated with persistent musculoskeletal pain as long-term post-COVID sequelae: a case-control study
Myalgia as a symptom at hospital admission by severe acute respiratory syndrome coronavirus 2 infection is associated with persistent musculoskeletal pain as long-term post-COVID sequelae: a case-control study
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DOI：
10.1097/j.pain.0000000000002306
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发表时间：
2021-12-01
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, Lars
中科院分区：
文献类型：
--
作者：
Fernandez-de-las-Penas, Cesar;Rodriguez-Jimenez, Jorge;Arendt-Nielsen, Lars
这项研究调查了患者在入院时经历的COVID相关肌痛与COVID后症状之间的关系。进行了一项病例对照研究，包括2020年2月20日至5月31日期间因COVID-19住院的患者。入院时报告肌痛的患者和无肌痛的患者计划在出院后7个月进行电话访谈。从病历中收集住院和临床数据。评估了COVID后症状列表，并关注肌肉骨骼疼痛。焦虑和抑郁症状以及睡眠质量也进行了评估。在总共1200名住院的COVID-19患者中，在出院后7.2个月（SD 0.6）对入院时有肌痛的369名和无肌痛的369名患者进行了评估。与没有肌痛的患者（13%）相比，入院时有肌痛的患者（20%）中有更大比例（P = 0.03）显示出>= 3种COVID后症状。与没有肌痛的患者相比，出现肌痛的患者比例更高（比值比1.41，95%置信区间1.04-1.90），表现出COVID后肌肉骨骼疼痛。总样本中COVID后肌肉骨骼疼痛的患病率为38%。50%先前存在肌肉骨骼疼痛的个体在COVID-19后症状恶化。肌痛组和非肌痛组在疲劳、呼吸困难、焦虑/抑郁水平或睡眠质量方面没有差异。入院时肌痛的存在与先前存在的肌肉骨骼疼痛史相关（OR 1.62，95%置信区间1.10-2.40）。总之，急性期的肌痛与作为COVID后长期后遗症的肌肉骨骼疼痛相关。此外，有一半既存疼痛状况的患者经历了其先前综合征的持续恶化。
This study investigated the association between COVID-related myalgia experienced by patients at hospital admission and the presence of post-COVID symptoms. A case-control study including patients hospitalised due to COVID-19 between February 20 and May 31, 2020, was conducted. Patients reporting myalgia and patients without myalgia at hospital admission were scheduled for a telephone interview 7 months after hospital discharge. Hospitalisation and clinical data were collected from medical records. A list of post-COVID symptoms with attention to musculoskeletal pain was evaluated. Anxiety and depressive symptoms, and sleep quality were likewise assessed. From a total of 1200 hospitalised patients with COVID-19, 369 with and 369 without myalgia at hospital admission were assessed 7.2 months (SD 0.6) after hospital discharge. A greater proportion (P = 0.03) of patients with myalgia at hospital admission (20%) showed >= 3 post-COVID symptoms when compared with individuals without myalgia (13%). A higher proportion of patients presenting myalgia (odds Rratio 1.41, 95% confidence interval 1.04-1.90) exhibited musculoskeletal post-COVID pain when compared to those without myalgia. The prevalence of musculoskeletal post-COVID pain in the total sample was 38%. Fifty percent of individuals with preexisting musculoskeletal pain experienced a worsening of their symptoms after COVID-19. No differences in fatigue, dyspnoea, anxiety/depressive levels, or sleep quality were observed between myalgia and nonmyalgia groups. The presence of myalgia at hospital admission was associated with preexisting history of musculoskeletal pain (OR 1.62, 95% confidence interval 1.10-2.40). In conclusion, myalgia at the acute phase was associated with musculoskeletal pain as long-term post-COVID sequelae. In addition, half of the patients with preexisting pain conditions experienced a persistent exacerbation of their previous syndromes.