Optic neuritis in African Americans
Optic neuritis in African Americans
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DOI：
10.1001/archneur.55.2.186
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发表时间：
1998-02-01
影响因子：
--
通讯作者：
Lynn, MJ
中科院分区：
文献类型：
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作者：
Phillips, PH;Newman, NJ;Lynn, MJ
目的：描述非裔美国人脱髓鞘性视神经炎的临床特征。方法：回顾性分析了1989年至1996年间在埃默里大学眼科中心（埃默里）神经眼科单位和佐治亚州亚特兰大市格雷迪纪念医院眼科诊所（格雷迪）检查的所有诊断为视神经炎的患者的病历。本研究纳入了年龄在15 - 55岁之间的非裔美国人和白色患者，这些患者首次发作急性视神经炎，原因不明或脱髓鞘。研究患者包括在Emery检查的23名非洲裔美国人患者和56名白色患者以及在Grady检查的10名非洲裔美国人患者。非裔美国人研究患者、白色研究患者和视神经炎治疗试验（ONT）患者之间的性别无显著差异（P= 0.36）、年龄（P= 0.73）或视神经炎初始发作时是否存在椎间盘水肿（P= 0.40）、磁共振成像发现的病变（P= 0.43）或多发性硬化（P= 0.54）。与埃默里白色患者（31例患者中的12例[39%]; P= 0.002）和ONT患者（448例患者中的161例[36%]; P= 0.002）相比，埃默里非裔美国人患者出现更频繁的严重视力丧失（14例患者中的13例[93%]视力小于或等于20/200）。
Objective: To describe the clinical profile of demyelinating optic neuritis in African Americans.Methods: The medical records of all patients with a diagnosis of optic neuritis examined at the Neuro-Ophthalmology Unit at the Emery University Eye Center (Emery) and at the Grady Memorial Hospital Eye Clinic (Grady), Atlanta, Ga, between 1989 and 1996 were retrospectively reviewed.Patients: African American and white patients, aged 15 through 55 years, with a single initial episode of acute optic neuritis of unknown or demyelinative origin were included in the study. Study patients included 23 African American patients and 56 white patients examined at Emery as well as 10 African American patients examined at Grady.Results: There were no significant differences among the African American study patients, the white study patients, and patients from the Optic Neuritis Treatment Trial (ONTT) regarding sex (P=.36), age (P=.73), or the presence of disc edema (P=.40), lesions found on magnetic resonance imaging (P=.43), or multiple sclerosis (P=.54) at the onset of an initial episode of optic neuritis. The Emery African American patients presented with more frequent severe visual loss (13 [93%] of 14 patients with a visual acuity less than or equal to 20/200) compared with Emery white patients (12 [39%] of 31 patients; P=.002) and with ONTT patients (161 [36%] of 448 patients; P