Gold nanoparticles for photoacoustic imaging.
Gold nanoparticles for photoacoustic imaging.
复制标题
用于光声成像的金纳米粒子
DOI：
10.2217/nnm.14.169
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Li W;Chen X
光声（PA）成像是一种生物医学成像模式，通过使用内源性和外源性造影剂提供有关组织细胞和分子特征的功能信息。PA成像剂的开发已经付出了巨大的努力，并且由于其固有的和几何诱导的光学性质，作为外源性造影剂的金纳米颗粒具有用于PA成像的巨大潜力。最常用于PA成像的基于金的纳米颗粒包括球体、棒、壳、棱柱、笼、星和囊泡。本文概述了利用这些金纳米材料进行癌症、动脉粥样硬化斑块、脑功能和图像引导治疗的PA成像的研究现状。
Photoacoustic (PA) imaging is a biomedical imaging modality that provides functional information regarding the cellular and molecular signatures of tissue by using endogenous and exogenous contrast agents. There has been tremendous effort devoted to the development of PA imaging agents, and gold nanoparticles as exogenous contrast agents have great potential for PA imaging due to their inherent and geometrically induced optical properties. The gold-based nanoparticles that are most commonly employed for PA imaging include spheres, rods, shells, prisms, cages, stars and vesicles. This article provides an overview of the current state of research in utilizing these gold nanomaterials for PA imaging of cancer, atherosclerotic plaques, brain function and image-guided therapy.