Phorbol esters affect pituitary growth hormone (GH) and prolactin release: the interaction with GH releasing factor, somatostatin and bromocriptine.
Phorbol esters affect pituitary growth hormone (GH) and prolactin release: the interaction with GH releasing factor, somatostatin and bromocriptine.
复制标题
佛波酯影响垂体生长激素 (GH) 和催乳素的释放：与 GH 释放因子、生长抑素和溴隐亭的相互作用。
DOI：
10.1016/0014-2999(85)90644-2
复制
发表时间：
1985
影响因子：
5
通讯作者：
Cronin,MJ
中科院分区：
文献类型：
--
作者：
Summers,ST;Canonico,PL;MacLeod,RM;Rogol,AD;Cronin,MJ
Phorbol esters are tumor promotors that directly stimulate protein kinase C activity. We asked whether these agents affect basal or receptor initiated alterations in growth hormone (GH) and prolactin release. In 4 h incubations of anterior pituitary cells, phorbol esters enhanced basal and GH releasing factor (GRF)-induced GH release. Somatostatin reduced by 38% the 4-fold stimulation of GH release induced by phorbol ester. These tumor promoters also reversed the ability of bromocriptine, a dopamine agonist, to inhibit prolactin release, with no apparent effect on basal prolactin secretion. When these agents were applied for 24 h, an increase in the basal release of both GH and prolactin was apparent. These data lead us to suggest that an intact protein kinase C system may be necessary for the full expression of GRF-stimulated GH release and dopaminergic inhibition of prolactin release.
