Focal nodular hyperplasia of the liver -: A comprehensive pathologic study of 305 lesions and recognition of new histologic forms
Focal nodular hyperplasia of the liver -: A comprehensive pathologic study of 305 lesions and recognition of new histologic forms
复制标题
DOI：
10.1097/00000478-199912000-00001
复制
发表时间：
1999-12-01
影响因子：
5.6
通讯作者：
Degott, C
中科院分区：
文献类型：
--
作者：
Nguyen, BN;Fléjou, JF;Degott, C
局灶性结节增生的非典型组织学变异已被报道，有时难以识别。为了描述局灶性结节增生的形态谱，我们研究了168例手术切除的305个病变。通过统计学分析建立临床形态学相关性。患者中女性150例，男性18例（性别比例8:1，中位年龄38岁）。单发病灶128例（76.2%），2 ~ 30个病灶40例（23.8%）。305个病灶的直径均为1毫米至19厘米。只有49%的病变有一到三个肉眼可见的疤痕。组织学上，245例（80.3%）病变为经典型，60例（19.7%）病变为非经典型。后者分为毛细血管扩张型局灶性结节性增生（47例）、增生性和腺瘤性混合增生（5例）和大细胞型异型增生（8例）。一些良性或恶性肿瘤被发现与这些病变有关。这一系列回顾性的大范围局灶性结节增生显示了其经典和非经典形式的相对发生率。没有中心瘢痕可以解释一些病例术前诊断困难的原因。本研究的形态学诊断标准需要进一步的前瞻性评价。
Atypical histologic variants of focal nodular hyperplasia have been reported and are sometimes difficult to recognize. To characterize the morphologic spectrum of focal nodular hyperplasia, we studied 305 lesions surgically resected from 168 patients. Clinicomorphologic correlations were established by statistical analyses. The patients included 150 women and 18 men (sex ratio, 8:1; median age, 38 years). One hundred twenty-eight (76.2%) patients had solitary lesions, and 40 (23.8%) had 2 to 30 lesions. All 305 lesions measured I mm to 19 cm in diameter. Only 49% of these lesions had one to three macroscopic scars. Histologically, 245 (80.3%) lesions were of classical form, and 60 (19.7%) lesions were nonclassical. The latter were classified as focal nodular hyperplasia of telangiectatic form (47 lesions), of mixed hyperplastic and adenomatous form (five lesions), and with atypia of large cell type (eight lesions). Several benign or malignant tumors were found in association with these lesions. This large retrospective series of focal nodular hyperplasia shows the relative incidence of its classical and nonclassical forms. The absence of a central scar could explain the difficult preoperative diagnosis of some of the cases. The morphologic diagnostic criteria in this study require further prospective evaluation.