REGULATION OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY BY HUMAN CHORIONIC-GONADOTROPIN, ANDROGENS, AND ANTIANDROGENS IN CULTURED TESTICULAR CELLS
REGULATION OF 3-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY BY HUMAN CHORIONIC-GONADOTROPIN, ANDROGENS, AND ANTIANDROGENS IN CULTURED TESTICULAR CELLS
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DOI：
10.1111/j.1749-6632.1984.tb38367.x
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发表时间：
1984-01-01
影响因子：
5.2
通讯作者：
HSUEH, AJW
中科院分区：
文献类型：
--
作者：
GALARRETA, CMR;FANJUL, LF;HSUEH, AJW
结论：（1）雄激素通过雄激素受体介导的过程抑制基础和hCG刺激的3 P-HSD活性。(2)hCG在无雄激素条件下刺激3 P-HSD活性。(3)雄激素介导的3 P-HSD活性抑制可能部分解释了睾丸内超短环负反馈机制，雄激素通过该机制调节自身的产生。
Conclusions:(1) Androgens inhibit basal and hCG-stimulated 3P-HSD activity through an androgen receptor-mediated process.(2) hCG stimulates 3P-HSD activity under androgen-free conditions.(3) Androgen-mediated inhibition of 3P-HSD activity may account, in part, for the intratesticular ultra short-loop negative feedback mechanism whereby androgens regulate their own production.