Predictive value of P wave terminal force in lead V1 for atrial fibrillation: A meta-analysis
Predictive value of P wave terminal force in lead V1 for atrial fibrillation: A meta-analysis
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DOI：
10.1111/anec.12739
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发表时间：
2020-02-05
影响因子：
1.9
通讯作者：
Liu, Jinlai
中科院分区：
文献类型：
--
作者：
Huang, Zhuoshan;Zheng, Zhenda;Liu, Jinlai
一些研究探讨了V1导联（PTFV1） P波末端力与房颤（AF）发生风险的关系，但结果存在争议。本荟萃分析旨在探讨PTFV1异常是否可以预测房颤的发生。方法检索PubMed、Embase和Cochrane图书馆数据库，检索2018年8月25日之前发表的文章。采用随机效应模型计算AF发生的合并优势比（or），探讨PTFV1的意义。结果共纳入12项研究，共纳入51372名受试者，其中9项研究将PTFV1作为分类变量，4项研究将PTFV1作为连续变量。作为分类变量，PTFV1异常（>0.04 mm s）与AF发生显著相关，合并OR为1.39（95%可信区间[CI] 1.08-1.79, p = 0.01）。亚组分析发现，血液透析患者（OR = 4.89, 95% CI 2.54-9.90, p < .001）和急性缺血性卒中患者（OR = 1.60, 95% CI 1.14-2.25, p = .007）的研究的OR值高于一般人群（OR = 1.15, 95% CI 1.03-1.29, p = .01）。来自欧洲的研究（OR = 1.05, 95% CI 0.91-1.20, p = 0.51）与亚洲（OR = 1.89, 95% CI 1.38-2.60, p < 0.001）和美国（OR = 1.43, 95% CI 1.19-1.72, p < 0.001）相比，终点的OR较低。作为一个连续变量，PTFV1也与AF发生显著相关，每1个标准差（SD）变化的投票OR为1.27 （95% CI 1.02-1.59, p = 0.03）。结论PTFV1与房颤发生风险显著相关，可作为有或无心血管疾病人群房颤发生的良好预测指标。
Background Several studies have explored the association between P wave terminal force in lead V1 (PTFV1) and risk of atrial fibrillation (AF) occurrence, but the results were controversial. This meta-analysis aimed to examine whether abnormal PTFV1 could predict AF occurrence.Methods We searched PubMed, Embase, and Cochrane Library databases for articles published before August 25, 2018. Pooled odds ratios (ORs) of AF occurrence were calculated using random-effects models to explore the significance of PTFV1.Results A total of 12 studies examining 51,372 participants were included, with 9 studies analyzing PTFV1 as a categorical variable and 4 studies analyzing PTFV1 as a continuous variable. As a categorical variable, abnormal PTFV1 (>0.04 mm s) was significantly associated with AF occurrence with a pooled OR of 1.39 (95% confidence interval [CI] 1.08-1.79, p = .01). Subgroup analysis found that ORs of studies in hemodialysis patients (OR = 4.89, 95% CI 2.54-9.90, p < .001) and acute ischemic stroke patients (OR = 1.60, 95% CI 1.14-2.25, p = .007) were higher than general population (OR = 1.15, 95% CI 1.03-1.29, p = .01). Studies from Europe (OR = 1.05, 95% CI 0.91-1.20, p = .51) yielded lower OR of endpoints compared with Asia (OR = 1.89, 95% CI 1.38-2.60, p < .001) and United States (OR = 1.43, 95% CI 1.19-1.72, p < .001). As a continuous variable, PTFV1 was also significantly associated with AF occurrence with a polled OR per 1 standard deviation (SD) change of 1.27 (95% CI 1.02-1.59, p = .03).Conclusions PTFV1 was significantly associated with the risk of AF and was considered to be a good predictor of AF occurrence in population with or without cardiovascular diseases.