Superabsorbent polysaccharide hydrogels based on pullulan derivate as antibacterial release wound dressing
Superabsorbent polysaccharide hydrogels based on pullulan derivate as antibacterial release wound dressing
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基于支链淀粉衍生物的超吸水性多糖水凝胶作为抗菌缓释伤口敷料
DOI：
10.1002/jbm.a.33045
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发表时间：
2011-07-01
影响因子：
4.9
通讯作者：
Zhang, Xingdong
中科院分区：
文献类型：
--
作者：
Li, Huanan;Yang, Jing;Zhang, Xingdong
为了完成理想的伤口敷料，基于天然多糖的水凝胶是通过化学交联成合成的。确定水凝胶膜（1 mm厚）的拉伸强度范围为0.663至1.097 MPa，成比例地与交联的程度和水含量成分。水中水凝胶的肿胀研究显示出明显的吸水性能，肿胀比高达4000％，从而为水凝胶提供了快速的止血能力，并防止了伤口床的积累。发现水蒸气的传输速率和水的水分在2213-3498g/m（2）/天和34.74-45.81％（6天后）的范围内，表明水凝胶可以维持潮湿的环境伤口床，这可以防止伤口床的脱水并防止结ab地层。生物相容性测试表明，水凝胶不是细胞毒性的。水凝胶可以加载抗菌剂并有效抑制细菌增殖，以保护伤口免受细菌侵袭。这些结果表明，作为新的理想伤口穿着材料，在这项研究中制备的Pullulan水凝胶可能具有很高的潜力。 （c）2011 Wiley Periconicals，Inc。J Biomed Mater Res a：98a：31-39，2011。
To accomplish ideal wound dressing, hydrogels based on a natural polysaccharide, pullulan were synthesized by chemical cross-linking. The tensile strengths of the hydrogel films (1 mm thick) were determined to range from 0.663 to 1.097 MPa in proportion to cross-linking degrees and water contents. The swelling study of the hydrogels in water showed remarkable water absorption property with swelling ratio up to 4000%, which provided the hydrogel with quick hemostatic ability and prevent the wound bed from accumulation of exudates. The water vapor transmission rate and water retention of the hydrogels were found to be in the range of 2213-3498g/m(2)/day and 34.74-45.81% (after 6 days), indicating that the hydrogel can maintain a moist environment over wound bed, which could prevent the dehydration of the wound bed and prevent the scab formation. Biocompatibility test revealed that the hydrogels were not cytotoxic. The hydrogel could load antimicrobial agents and effectively suppress bacterial proliferation to protect the wound from bacterial invasion. These results suggest that the pullulan hydrogels prepared in this study may have high potential as new ideal wound-dressing materials. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 98A: 31-39, 2011.