Anxiogenic action of caffeine: an experimental study in rats
Anxiogenic action of caffeine: an experimental study in rats
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DOI：
10.1177/026988119701100304
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发表时间：
1997-01-01
影响因子：
4.1
通讯作者：
Chakrabarti, A
中科院分区：
文献类型：
--
作者：
Bhattacharya, SK;Satyan, KS;Chakrabarti, A
咖啡因（10、25和50 mg/kg，i. p.）并与育亨宾（2 mg/kg，i. p.）实验方法为旷场、高架十字迷宫、社会互动和新颖性抑制摄食潜伏期试验。咖啡因产生了剂量相关的行为变化，这是定性相似的育亨宾诱导的，这表明在啮齿类动物的抗焦虑活性。因此，在旷场试验中，这两种药物都减少了阿姆斯壮和后腿，并增加了不动性和排便。他们减少了条目的数量和时间花在高架十字迷宫的开放臂，减少了配对大鼠的社会互动，并增加了48小时食物剥夺大鼠在陌生环境中的进食潜伏期。劳拉西泮，一种众所周知的苯二氮类抗焦虑药，减弱了咖啡因和育亨宾的致焦虑作用。亚慢性施用咖啡因（50 mg/kg，i. p.）在高架十字迷宫试验中，在不同组的动物中诱导了显著程度的耐受性，这在处理14和21天后具有统计学显著性。然而，育亨宾没有诱导类似的耐受性。当咖啡因（50 mg/kg，i. p.）在给药21天后撤回，对于另一组大鼠，48小时后观察到显著的撤回焦虑，如高架十字迷宫试验所示。研究支持咖啡因引起的焦虑，对持续使用的焦虑的耐受性，以及慢性含咖啡因饮料使用者的戒断焦虑的临床证据。
The anxiogenic action of caffeine (10, 25 and 50 mg/kg, i.p.) was investigated in rats and compared with that of yohimbine (2 mg/kg, i.p.). The experimental methods used were the open-field, elevated plus-maze, social interaction and novelty-suppressed feeding latency tests. Caffeine produced a dose-related profile of behavioural changes, which were qualitatively similar to those induced by yohimbine and which indicate an anxiogenic activity in rodents. Thus, both the drugs reduced ambulation and rears, and increased immobility and defaecation in the open-field test. They decreased the number of entries and time spent on the open arms of the elevated-plus maze, reduced social interaction in paired rats and increased the feeding latency in an unfamiliar environment in 48-h food-deprived rats. Lorazepam, a well known benzodiazepine anxiolytic agent, attenuated the anxiogenic effects of caffeine and yohimbine. Subchronic administration of caffeine (50 mg/kg, i.p.) for 21 days, in different groups of animals, induced a significant degree of tolerance in the elevated plus-maze test, which was statistically significant after 14 and 21 days' treatment. Yohimbine, however, did not induce similar tolerance. When caffeine (50 mg/kg, i.p.) was withdrawn after 21 days' administration, to a separate group of rats, significant withdrawal anxiety was observed 48 h later as noted in the elevated plus-maze test. The investigations support clinical evidence of caffeine-induced anxiety, tolerance to anxiety on continued use, and withdrawal anxiety in chronic caffeine-containing beverage users.