Shear wave elastography may be sensitive and more precise than transient elastography in predicting significant fibrosis
Shear wave elastography may be sensitive and more precise than transient elastography in predicting significant fibrosis
复制标题
剪切波弹性成像在预测显着纤维化方面可能比瞬时弹性成像更敏感且更精确
DOI：
10.12998/wjcc.v8.i17.3730
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发表时间：
2020-09
影响因子：
1.1
通讯作者：
Guiqiang Wang
中科院分区：
文献类型：
--
作者：
Tiantian Yao;Jing Pan;Ji;an Qian;Hao Cheng;Yan Wang;Guiqiang Wang
BACKGROUND Noninvasive measurements including transient elastography (TE) and two-dimensional shear wave elastography (SWE) have been used clinically instead of liver biopsy for regular assessment of liver fibrosis in chronic hepatitis B (CHB) patients. AIM To investigate the diagnostic efficiency of SWE compared to TE by assessing independent influencing factors and performance for diagnosing significant fibrosis based on our cohort of treatment-naive CHB patients. METHODS Fifty-four treatment-naive CHB patients who underwent liver biopsy to determine whether to initiate antiviral therapy were enrolled. SWE, TE, serum tests and liver biopsy were performed for all participants. The fibrosis-4 and aspartate aminotransferase to platelet ratio index scores were also calculated. Potential independent influencing factors on SWE and TE values were analyzed. Based on liver pathology results, the agreement and correlation were determined, and a comparison of the two methods was performed. RESULTS There were 27 cases (50%) of mild fibrosis (F0-F2) and 27 (50%) cases of significant fibrosis (F3-F6); fibrosis was assessed with the Ishak scoring system. Multivariate linear regression analyses revealed that the fibrosis stage was the only factor that affected the SWE values (P < 0.001), whereas the total bilirubin level (P = 0.013) and fibrosis stage (P = 0.037) were independent factors that affected TE values. Orthogonal partial least squares discriminant analysis showed that the number of independent factors (VIP > 1) was higher for TE than SWE. Bland-Altman analysis showed satisfactory agreement between liver stiffness measurements (LSMs) of SWE and TE. Both SWE and TE could significantly discriminate significant fibrosis from mild fibrosis (P < 0.001). SWE exhibited a higher correlation with LSMs of liver fibrosis than TE (r = 0.65 and 0.50, P < 0.001). The diagnostic performance of SWE was better than that of TE for significant fibrosis (F > 2). The areas under the receiver operating characteristic curves of SWE and TE were 0.786 and 0.714, respectively. The optimal LSM cutoff values of SWE and TE were 9.05 kPa and 8.15 kPa, respectively. CONCLUSION Compared to the TE value, the SWE value was less affected by other factors. SWE may be more sensitive and precise than TE in predicting significant fibrosis (> F2) in CHB patients.
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影响因子：
2.9
作者：
Bende, Felix;Mulabecirovic, Anesa;Havre, Roald Flesland
通讯作者：
Havre, Roald Flesland
瞬时弹性成像在慢性乙型肝炎患者治疗中的当前作用。
DOI：
10.14366/usg.16023
发表时间：
2017-04
期刊：
Ultrasonography (Seoul, Korea)
影响因子：
--
作者：
Yu JH;Lee JI
通讯作者：
Lee JI
影响因子：
29.4
作者：
T. Chalmers
通讯作者：
T. Chalmers
影响因子：
13.5
作者：
通讯作者：
--
影响因子：
--
作者：
Krishna, Murli
通讯作者：
Krishna, Murli