Chromosomal speciation and molecular divergence - Accelerated evolution in rearranged chromosomes
Chromosomal speciation and molecular divergence - Accelerated evolution in rearranged chromosomes
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DOI：
10.1126/science.1080600
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发表时间：
2003-04-11
期刊：
影响因子：
56.9
通讯作者：
Barton, NH
中科院分区：
文献类型：
--
作者：
Navarro, A;Barton, NH
人类和他们最近的进化亲戚黑猩猩，在基因组DNA序列上有1.24%的相似之处。这些变化的部分积累在物种形成过程中，已经分开了两个谱系可能是特别相关的理解他们的差异的基础。我们分析了人类和黑猩猩的序列数据，以寻找物种形成理论模型预测的分歧和多态性模式。根据该模型，积极选择的变化应该积累在染色体中。两个物种之间固定的结构差异，如倒位。与共线染色体相比，在经历了结构重排的染色体中，蛋白质进化的速度要快2.2倍以上。此外，核苷酸变异性在重排的染色体中略低。这些分歧和多态性的模式可能是，至少部分，在人类和黑猩猩谱系物种形成事件的分子足迹。
Humans and their closest evolutionary relatives, the chimpanzees, differ in similar to1.24% of their genomic DNA sequences. The fraction of these changes accumulated during the speciation processes that have separated the two lineages may be of special relevance in understanding the basis of their differences. We analyzed human and chimpanzee sequence data to search for the patterns of divergence and polymorphism predicted by a theoretical model of speciation. According to the model, positively selected changes should accumulate in chromosomes that present. fixed structural differences, such as inversions, between the two species. Protein evolution was more than 2.2 times faster in chromosomes that had undergone structural rearrangements compared with colinear chromosomes. Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages.