Magnetic resonance spectroscopy of the cervical cord in amyotrophic lateral sclerosis
Magnetic resonance spectroscopy of the cervical cord in amyotrophic lateral sclerosis
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DOI：
10.3109/17482968.2010.515223
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发表时间：
2011-05-01
影响因子：
--
通讯作者：
Benatar, Michael
中科院分区：
文献类型：
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作者：
Carew, John D.;Nair, Govind;Benatar, Michael
本研究的目的是使用磁共振波谱（MRS）比较ALS患者和健康对照者颈髓中的代谢物比率。14例ALS患者和16例对照者使用3 T扫描仪进行扫描。沿脊髓主轴沿着放置一个矩形体素（8 X 5 X 35 mm），下限位于C2椎体的下方。MRS采用点分辨光谱（PRESS）序列进行。使用三脉冲化学位移选择性（CHESS）饱和序列抑制水信号。从代谢物峰计算胆碱（Cho）、肌酸（Cr）、肌醇（Myo）和NAA的相对浓度。用Wilcoxon秩和检验评估ALS患者和对照之间代谢物比率的差异。通过Pearson相关性确定代谢物比值与临床指标（ALSFRS-R和FVC）的关系。ALS患者的NAA/Cr和NAA/Myo比值分别降低了40%和38%。NAA/Myo和NAA/Cho的降低与FVC显著相关，相关系数分别为0.66和0.60。总之，磁共振波谱可以可靠地获得从颈脊髓ALS。颈髓MRS可能是疾病进展的有用生物标志物。
The objective of this study was to use magnetic resonance spectroscopy (MRS) to compare metabolite ratios in the cervical spinal cord of ALS patients to healthy controls. Fourteen ALS patients and 16 controls were scanned using a 3T scanner. A rectangular voxel (8 X 5 X 35 mm) was placed along the main axis of the cord with the lower limit at the inferior aspect of the C2 vertebral body. MRS was performed with a point-resolved spectroscopy (PRESS) sequence. Water signals were suppressed using a three-pulse chemical shift selective (CHESS) saturation sequence. Relative concentrations of choline (Cho), creatine (Cr), myo-inositol (Myo), and NAA were computed from metabolite peaks. Differences in metabolite ratios between ALS patients and controls were assessed with a Wilcoxon rank-sum test. The relationship of metabolite ratios to clinical measures (ALSFRS-R and FVC) was determined by Pearson correlation. The NAA/Cr and NAA/Myo ratios were reduced by 40% and 38%, respectively, in ALS patients. The reduction in NAA/Myo and NAA/Cho correlated significantly with FVC, with correlation coefficients of 0.66 and 0.60, respectively. In conclusion, MR spectra can reliably be obtained from the cervical spinal cord in ALS. MRS of the cervical cord may be a useful biomarker of disease progression.