Pulmonary function in young smokers: male-female differences.
Pulmonary function in young smokers: male-female differences.
复制标题
年轻吸烟者的肺功能：男女差异。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
P. Terry
中科院分区：
文献类型：
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作者：
S. Enjeti;B. Hazelwood;S. Permutt;H. Menkes;P. Terry
为探讨青年吸烟者肺功能异常的类型及相关的病理生理机制，对205名18 ~ 25岁的志愿者进行了多种肺功能检查。男性和女性吸烟者之间的差异进行了观察。肺功能异常与小气道功能障碍一致，男性吸烟者，但在女性吸烟者中没有。在男性和女性吸烟者中均观察到高肺容量时用力呼气流量减少，提示大气道功能障碍。与肺血管系统异常一致的CO弥散能力下降见于两种性别的吸烟者，但在女性中更为突出。因为男性比女性更容易发生慢性阻塞性肺病，即使在调整吸烟的情况下，因为女性比男性更容易发生原发性肺动脉高压，这些慢性疾病可能反映了两种性别对香烟等药物的不同病理生理反应。
To delineate the pattern of pulmonary function abnormalities and associated pathophysiologic mechanisms in young smokers, 205 volunteers between the ages of 18 and 25 were studied with a variety of pulmonary function tests. Differences between male and female smokers were observed. Pulmonary function abnormalities consistent with small airway dysfunction were noted in male smokers, but not in female smokers. Decreased forced expiratory flows at high lung volumes suggesting large airway dysfunction were noted in both male and female smokers. Decreases in diffusing capacity for CO consistent with abnormalities of the pulmonary vascular system were seen in smokers of both sexes, but were more prominent in females. Because men develop chronic obstruction pulmonary disease more frequently than do women even when adjustments for smoking are made, and because women develop primary pulmonary hypertension more frequently than do men, these chronic diseases may reflect distinct pathophysiologic response of the 2 sexes to agents such as cigarettes.