MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA
MiR-10a and miR-181c regulate collagen type I generation in hypertrophic scars by targeting PAI-1 and uPA
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MiR-10a 和 miR-181c 通过靶向 PAI-1 和 uPA 调节增生性疤痕中 I 型胶原蛋白的生成
DOI：
10.1016/j.febslet.2014.12.024
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发表时间：
2015-01-30
期刊：
影响因子：
3.5
通讯作者：
Hu, Da-Hai
中科院分区：
文献类型：
--
作者：
Li, Chao;Zhu, Hua-Yu;Hu, Da-Hai
Urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) have been proposed to play key roles in extracellular matrix (ECM) deposition in hypertrophic scars (HS). Here, we found that in HS fibroblasts (HFs) miR-181c and miR-10a were differentiallyexpressed and targeted uPA and PAI-1, respectively. The production of Type 1 collagen (Col1) was inhibited by miR-181c knockdown or miR-10a overexpression in HFs, and this resulted in increased levels of metalloproteinase 1 (MMP1). These results suggest that the miR-181c-uPA and miR-10a-PAI-1 regulatory pathways have an integral role in HS pathogenesis. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
