A vaccine cold chain freezing study in PNG highlights technology needs for hot climate countries
A vaccine cold chain freezing study in PNG highlights technology needs for hot climate countries
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DOI：
10.1016/j.vaccine.2006.08.028
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发表时间：
2007-01-08
期刊：
影响因子：
5.5
通讯作者：
Clements, C. John
中科院分区：
文献类型：
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作者：
Wirkas, Theo;Toikilik, Steven;Clements, C. John
在巴布亚新几内亚莫尔兹比港的国家疫苗商店，14台数据记录仪装满了疫苗瓶，并被送往卫生系统的外围地点。数据记录仪在它们沿着冷链的过程中记录的温度表明，热损伤不太可能发生，但所有的小瓶都在某个时间暴露在冰点温度下。最常见的冰冻情况是在运输过程中。冰冻的情况很可能是由于把小瓶装得太靠近冰袋，而冰袋本身太冷。它们之间没有足够的绝缘。这种情况已得到纠正，数据记录器的重复派遣表明该系统确实已得到纠正。随着更多多抗原疫苗的引入，对冷冻敏感的疫苗的价格也在上涨，因此避免冷冻损害变得更加重要。这种评估冷链功能的低成本高科技方法被强烈推荐给发展中国家和工业化国家，应该定期使用，以检查疫苗冷链的完整性。该研究强调需要技术解决方案来避免疫苗冻结，特别是在气候炎热的国家。(c) 2006 Elsevier Ltd.版权所有。
Fourteen data loggers were packed with vaccine vials at the national vaccine store, Port Moresby, Papua New Guinea (PNG), and sent to peripheral locations in the health system. The temperatures that the data loggers recorded during their passage along the cold chain indicated that heat damage was unlikely, but that all vials were exposed to freezing temperatures at some time. The commonest place where freezing conditions existed was during transport. The freezing conditions were likely induced by packing the vials too close to the ice packs that were themselves too cold. and with insufficient insulation between them. This situation was rectified and a repeat dispatch of data loggers demonstrated that the system had indeed been rectified. Avoiding freeze damage becomes even more important as the price of freeze-sensitive vaccines increases with the introduction of more multiple-antigen vaccines. This low-cost high-tech method of evaluating the cold chain function is highly recommended for developing and industrialized nations and should be used oil a regular basis to check the integrity of the vaccine cold chain. The study highlights the need for technological solutions to avoid vaccine freezing, particularly in hot climate countries. (c) 2006 Elsevier Ltd. All rights reserved.