MRI Detection of New Microbleeds in Patients With Ischemic Stroke Five-Year Cohort Follow-Up Study
MRI Detection of New Microbleeds in Patients With Ischemic Stroke Five-Year Cohort Follow-Up Study
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DOI：
10.1161/strokeaha.109.568469
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发表时间：
2010-01-01
期刊：
影响因子：
8.3
通讯作者：
Werring, David J.
中科院分区：
文献类型：
--
作者：
Gregoire, Simone M.;Brown, Martin M.;Werring, David J.
背景和目的：对于缺血性卒中患者脑微出血的发生知之甚少。我们研究了新的微出血的发病率在一个队列的患者缺血性中风或短暂性脑缺血发作筛选微bleeds在baseline.Methods-Twenty-One缺血性中风或短暂性脑缺血发作的存活患者进行了随访后，平均间隔5.5年，重复MRI和临床评估。新的微出血的预测因素进行了logistic regression. Results-of基线时有微出血的患者，50%的患者在随访时有新的微出血，相比之下，没有基线微出血的患者有8%（P=0.047）。基线微出血的存在预示着新的微出血（OR，12; 95%CI，1.02至141.34; P=0.048），平均收缩压也是如此（OR，1.28/单位增加; 95%CI，1.23至1.33; P = 0.048）。
Background and Purpose-Little is known about the development of cerebral microbleeds in patients with ischemic stroke. We studied the incidence of new microbleeds in a cohort of patients with ischemic stroke or transient ischemic attack screened for microbleeds at baseline.Methods-Twenty-one surviving patients with ischemic stroke or transient ischemic attack were followed up after a mean interval of 5.5 years with repeat MRI and clinical assessment. Predictors of new microbleeds were tested in logistic regression.Results-Of patients with microbleeds at baseline, 50% had new microbleeds at follow-up compared with 8% of those without baseline microbleeds (P=0.047). The presence of microbleeds at baseline predicted new microbleeds (OR, 12; 95% CI, 1.02 to 141.34; P=0.048), as did mean systolic blood pressure (OR, 1.28 per unit increase; 95% CI, 1.23 to 1.33; P