Sex differences in interval timing and attention to time in C57Bl/6J mice.
Sex differences in interval timing and attention to time in C57Bl/6J mice.
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DOI：
10.1016/j.bbr.2017.02.023
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发表时间：
2017-05-01
影响因子：
2.7
通讯作者：
Buhusi CV
中科院分区：
文献类型：
--
作者：
Buhusi M;Bartlett MJ;Buhusi CV
间隔时间对于决策和运动控制至关重要，并且在许多神经精神疾病中受损。以前的研究检查了不同品系或基因改变小鼠的时间，但在相同的实验环境中，雄性和雌性小鼠的时间并不平行。我们调查了时间和注意力的时间在男性和女性C57 Bl/6 J小鼠，当提出的间隙在定时刺激，新的听觉干扰在不间断的定时刺激，间隙+干扰组合。在时间准确性和精确性方面没有发现性别差异。然而，差距+干扰项组合的呈现在男性中过重置时间，但在女性中的影响要小得多。过度重置策略以前曾被报道与情绪干扰（例如，先前与足电击配对），但不与中性干扰器配对。这些结果揭示了性别差异的注意门控/转换或工作记忆的时间。
Interval timing is crucial for decision-making and motor control and is impaired in many neuropsychiatric disorders. Previous studies examined timing in various strains or genetically-altered mice, but not in parallel in male and female mice in the same experimental setting. We investigated timing and attention to time in male and female C57Bl/6J mice, when presented with gaps in the timed stimulus, novel auditory distracters presented during the un-interrupted timed stimulus, and gap+distracter combinations. No sex differences were found in regard to timing accuracy and precision. However, presentation of the gap+distracter combination over-reset timing in males but had a much smaller effect in females. The over-reset strategy was reported previously with emotional distracters (e.g., previously paired with footshock) but not with neutral distracters. These results reveal sex differences in attentional gating/switching or working memory for time.