Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas.
Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas.
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Sonic Hedgehog信号通路的表达与胰腺导管内乳头状粘液性肿瘤的发生相关。
DOI：
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Shimosegawa
中科院分区：
文献类型：
--
作者：
K. Satoh;A. Kanno;S. Hamada;M. Hirota;Jun Umino;A. Masamune;S. Egawa;F. Motoi;M. Unno;T. Shimosegawa
Sonic Hedgehog(SHH)在癌前病变和胰腺癌中经常表达。最近的一项研究表明，它在胰腺导管内乳头状黏液性肿瘤(IPMN)中的表达高于胰腺癌。然而，其信号通路与IPMN的肿瘤发生之间的关系还没有很好的文献报道。应用一步定量实时定量逆转录聚合酶链式反应和免疫组织化学方法分别检测了15例19个IPMN和33例75个IPMN中SHH及其下游转录因子Gli1的表达。在IPMNS的19个皮损中，有8个皮损中检测到Shh和Gli1mRNAs。Shh和Gli1mRNAs可能分别在腺瘤和交界性癌细胞中上调。免疫组织化学分析还表明，SHH和Gli1的表达与细胞异型性的程度有关。这些发现表明，HH信号在IPMN中被激活，并在这些类型的肿瘤中参与了肿瘤的发生。
Sonic hedgehog (SHH) is frequently expressed in pre-cancerous lesions and carcinoma of the pancreas. A recent study revealed that its expression was higher in the intraductal papillary mucinous neoplasm (IPMN) of the pancreas than in the pancreatic carcinoma. However, the correlation between its signaling pathway and tumorigenesis of IPMN has not yet been well documented. We investigated the expression of mRNA and protein of SHH as well as its downstream transcription factor Gli1 in 19 microdissected lesions from 15 cases and in 75 lesions from 33 cases of the IPMN by one-step quantitative real-time reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. SHH and Gli1 mRNAs were detected in all the examined lesions and 8 out of 19 lesions in IPMNs, respectively. SHH and Gli1 mRNAs were likely to be up-regulated from the adenoma and from borderline to carcinoma cells, respectively. Immunohistochemical analysis also reported that SHH and Gli1 expression was correlated with the grade of cell atypia. These findings suggested that HH signaling was activated in IPMNs and contributed to tumorigenesis in these types of neoplasms.
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影响因子：
10.5
作者：
di Magliano, Marina Pasca;Sekine, Shigeki;Hebrok, Matthias
通讯作者：
Hebrok, Matthias
影响因子：
11.2
作者：
Prasad, NB;Biankin, AV;Leach, SD
通讯作者：
Leach, SD
DOI：
10.1242/dev.127.22.4905
发表时间：
2000
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Hebrok,M;Kim,SK;StJacques,B;McMahon,AP;Melton,DA
通讯作者：
Melton,DA
DOI：
10.1073/pnas.0404956101
发表时间：
2004-08-24
影响因子：
11.1
作者：
Sanchez, P;Hern치ndez, AM;Altaba, ARI
通讯作者：
Altaba, ARI