Increased tissue deposition and decreased excretion of platinum following administration of cisplatin to cisplatin-pretreated animals
Increased tissue deposition and decreased excretion of platinum following administration of cisplatin to cisplatin-pretreated animals
复制标题
给顺铂预处理的动物施用顺铂后，组织沉积增加，铂排泄减少
DOI：
10.1007/bf00255909
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发表时间：
2004
影响因子：
3
通讯作者：
V. Schweitzer
中科院分区：
文献类型：
--
作者：
C. Litterst;V. Schweitzer
在IV施用195 mPt标记的顺铂之前，用顺铂（10 mg/kg）IP预处理豚鼠不同时间。195 m铂在预处理动物组织中的浓度高于对照动物。在预处理的动物中，来自预处理的兔子的亚细胞组分中的195 m铂的量类似地更高。放射性量似乎在接受大量预处理注射的动物中最大，即使所有组中给予的顺铂总量相等。放射性给药后第1天，仅接受预处理的动物BUN升高。与对照组动物相比，预处理组动物的铂尿排泄量显著减少。似乎顺铂预处理对肾脏的损害严重到足以使后续剂量的顺铂不能有效排泄，从而导致预处理动物中铂的组织沉积更大。
Guinea pigs were pretreated IP with cisplatin (10 mg/kg) for various times before IV administration of195mPtlabeled cisplatin. Concentrations of195mplatinum were greater in tissues of pretreated animals than in those of control animals. Amounts of195mplatinum in subcellular fractions from pretreated rabbits were similarly greater in pretreated animals. Amounts of radioactivity appeared to be greatest in animals receiving a larger number of pretreatment injections, even though the total amount of cisplatin administered was equal in all groups. BUN was elevated on day 1 after the radioactive dose only in those animals which had been pretreated. Urinary excretion of platinum was significantly less in pretreated than in control animals. It appears that pretreatment with cisplatin damages the kidney severely enough for subsequent doses of cisplatin not to be excreted as efficiently, thus leading to a greater tissue deposition of platinum in pretreated animals.