Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy.
Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy.
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DOI：
10.1186/s13287-016-0303-6
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发表时间：
2016-03-09
影响因子：
7.5
通讯作者：
Agrawal DK
中科院分区：
文献类型：
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作者：
Lee DE;Ayoub N;Agrawal DK
间充质干细胞（MSC）（也称为多能间充质基质细胞）具有自我更新和多谱系分化的能力，并且它们促进皮肤伤口愈合的能力已被充分表征。通过旁分泌相互作用，MSC加速伤口闭合，增加血管生成，促进伤口炎症的消退，有利地调节细胞外基质重塑，并促进具有正常结构和功能的皮肤再生。许多研究已经采用了新的方法来放大MSC的递送和功效。MSC的非传统来源，包括华顿氏胶和医疗废物材料，已经显示出与传统来源，如骨髓和脂肪组织相当的功效。也已经证明了将MSC引入伤口和增加MSC迁移到伤口区域的替代方法的潜力。利用MSC与M2巨噬细胞和microRNA之间的关联，增强MSC的免疫调节能力的方法已经显示出成功。增强血管生成能力的新措施也表现出有效性，通常通过增加促血管生成血管内皮生长因子的水平来证明。最后，低氧已被证明在增加MSC功效方面具有强大的伤口愈合潜力。我们对新研究的结果进行了批判性的回顾，这些研究显示了基于MSC的伤口愈合疗法的持续发展的前景，并为该领域的持续研究提供了方向。
Mesenchymal stem cells (MSCs) (also known as multipotent mesenchymal stromal cells) possess the capacity for self-renewal and multi-lineage differentiation, and their ability to enhance cutaneous wound healing has been well characterized. Acting via paracrine interactions, MSCs accelerate wound closure, increase angiogenesis, promote resolution of wound inflammation, favorably regulate extracellular matrix remodeling, and encourage regeneration of skin with normal architecture and function. A number of studies have employed novel methods to amplify the delivery and efficacy of MSCs. Non-traditional sources of MSCs, including Wharton’s jelly and medical waste material, have shown efficacy comparable to that of traditional sources, such as bone marrow and adipose tissue. The potential of alternative methods to both introduce MSCs into wounds and increase migration of MSCs into wound areas has also been demonstrated. Taking advantage of the associations between MSCs with M2 macrophages and microRNA, methods to enhance the immunomodulatory capacity of MSCs have shown success. New measures to enhance angiogenic capabilities have also exhibited effectiveness, often demonstrated by increased levels of proangiogenic vascular endothelial growth factor. Finally, hypoxia has been shown to have strong wound-healing potential in terms of increasing MSC efficacy. We have critically reviewed the results of the novel studies that show promise for the continued development of MSC-based wound-healing therapies and provide direction for continued research in this field.