Association of exposure to Chinese famine in early life with the incidence of hypertension in adulthood: A 22-year cohort study
Association of exposure to Chinese famine in early life with the incidence of hypertension in adulthood: A 22-year cohort study
复制标题
早年经历中国饥荒与成年高血压发病率的关系：一项 22 年队列研究
DOI：
10.1016/j.numecd.2019.07.008
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发表时间：
2019
影响因子：
3.9
通讯作者：
Chen Yongjie
中科院分区：
文献类型：
--
作者：
Zhao Rencheng;Duan Xiaoyu;Wu Ying;Zhang Qi;Chen Yongjie
背景和目的生命早期营养不良可能对成年后的健康产生终生影响。关于饥荒暴露与高血压风险之间关系的结论并不一致。本研究的目的是探讨暴露于中国饥荒与高血压事件的关系。方法与结果数据来源于中国健康与营养调查。所有纳入的参与者被分为5个出生队列：1962年或之后出生的无接触组（N = 2088）；胎儿暴露，1959 - 1961年（N = 880）；儿童早期暴露，1956年至1958年（N = 1 214）；儿童中期暴露，1953年至1955年（N = 1 287）；1949年至1952年间儿童晚期暴露（N = 1445）。高血压定义为收缩压/舒张压≥140/90 mmHg，使用高血压药物，或自我报告诊断。研究共纳入6 914名参与者。饥荒使男性高血压发病率降低（P= 0.0018、0.0001、<0.0001和<0.0001；HR分别为0.715、0.686、0.622和0.527）。同样，饥荒也可能降低农村地区的高血压发病率（P= 0.0013, <0.0001, <0.0001和<0.0001；HR分别为0.735,0.706,0.679和0.539）。饥荒严重程度与儿童期早期（P= 0.024）和儿童期晚期（P= 0.009）的饥荒暴露存在交互作用。结论中国饥荒使高血压发病率降低，尤其是在男性和农村地区。此外，这种暴露推迟了高血压发病的年龄。
Background and aimsUndernutrition in early life may have a lifelong effect on adult health. The conclusions on the association of exposure to famine with the risk of hypertension were inconsistent. The aim of this study was to examine the association of exposure to the Chinese famine with incident hypertension.Methods and resultsData were obtained from the China Health and Nutrition Survey. All included participants were divided into five birth cohorts: no exposure, born in or after 1962 (N = 2 088); fetal exposure, between 1959 and 1961 (N = 880); early childhood exposure, between 1956 and 1958 (N = 1 214); mid-childhood exposure, between 1953 and 1955 (N = 1 287); and late childhood exposure, between 1949 and 1952 (N = 1 445). Hypertension was defined as SBP/DBP ≥140/90 mmHg, use of hypertensive medications, or a self-reported diagnosis. A total of 6 914 participants were included. The exposure to famine decreased the incidence of hypertension (P= 0.0018, 0.0001, <0.0001, and <0.0001;HR: 0.715, 0.686, 0.622, and 0.527, respectively) in males. Similarly, the exposure to famine might also decrease incident hypertension in the rural areas (P= 0.0013, <0.0001, <0.0001, and <0.0001;HR: 0.735, 0.706, 0.679, and 0.539, respectively). There were interaction effects between famine severity and exposure to famine in early (P= 0.024) and late childhood (P= 0.009).ConclusionExposure to the Chinese famine decreased the incidence of hypertension, especially in males and in the rural areas. Furthermore, the exposure postponed the age at the onset of hypertension.