PEPTIDES COMPLEXED TO CYCLODEXTRIN FRAGMENT RATHER THAN DISSOCIATE WHEN SUBJECTED TO BLACKBODY INFRARED RADIATION
PEPTIDES COMPLEXED TO CYCLODEXTRIN FRAGMENT RATHER THAN DISSOCIATE WHEN SUBJECTED TO BLACKBODY INFRARED RADIATION
复制标题
受到黑体红外辐射时，肽与环糊精片段复合而不是解离
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
C. Lebrilla
中科院分区：
文献类型：
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作者：
S. Penn;Fei He;C. Lebrilla
黑体红外辐射解离用于探测肽-环糊精复合物的断裂行为。在这些条件下，缓激肽（及其一些类似物）与全甲基化β-环糊精结合形成的复合物经历肽片段化而不是复合物解离。活化能和指前因子从Arrhenius图构建在一个温度范围内（323和440 K之间）。当从肽中除去内含物的位点时，肽的片段化行为没有显著差异。进行分子动力学模拟，以更好地理解实验观察。
Blackbody infrared radiation dissociation is used to probe the fragmentation behavior of peptide−cyclodextrin complexes. Complexes formed by combining bradykinin (and some of its analogues) with permethylated β-cyclodextrin undergo peptide fragmentation rather than complex dissociation under these conditions. Activation energies and preexponential factors are obtained from Arrhenius plots constructed over a temperature range (between 323 and 440 K). The fragmentation behavior of the peptides does not differ considerably when the sites of inclusions are removed from the peptide. Molecular dynamics simulations are performed to better understand the experimental observations.