Variation in cellular tropism between isolates of Equine herpesvirus-1 in Foals
Variation in cellular tropism between isolates of Equine herpesvirus-1 in Foals
复制标题
马驹中马疱疹病毒 1 分离株的细胞向性差异
作者：
J. Patel;N. Edington;J. Mumford
对从一匹四肢瘫痪的马和一个流产胎儿中分离的马疱疹病毒1型（EHV-1）亚型分离株进行了相互比较，并与2型呼吸道分离株进行了比较。所有3株分离株均在呼吸道上皮细胞和巨噬细胞中检出。麻痹和胎儿亚型1分离株在回肠上皮中复制，这与体内粪便中病毒的回收有关。轻瘫亚型-1分离株也有一个predelection血管内皮细胞，特别是在鼻粘膜，但也在肺，中枢神经系统，肾上腺和thyroid.In的9个马驹接种轻瘫分离株2后肢功能障碍，4发展腹泻，这4个死亡与肠套叠。这些分离株之间的差异进行了讨论，在其他疱疹病毒。
SummarySubtype-1 isolates of Equine herpesvirus-1 (EHV-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. All 3 isolates were detected in the epithelium and macrophages of the respiratory tract. Both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faecesin vivo. The paresis subtype-1 isolate also had a predelection for vascular endothelial cells, particularly in the nasal mucosa, but also in the lungs, central nervous system, adrenal and thyroid.In the 9 foals inoculated with the paresis isolate two developed hind limb dysfunction, four developed diarrhoea, and one of these 4 died with an intussusception.The differences between these isolates are discussed in relation to other herpesviruses.