Clinical Significance of Serum Soluble E-cadherin in Colorectal Carcinoma
Clinical Significance of Serum Soluble E-cadherin in Colorectal Carcinoma
复制标题
DOI：
10.1016/j.jss.2011.11.009
复制
发表时间：
2012-06-15
影响因子：
2.2
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
--
作者：
Okugawa, Yoshinaga;Toiyama, Yuji;Kusunoki, Masato
背景资料。E-钙粘附素的表达与结直肠癌患者的预后有关，在恶性疾病患者中，血清可溶性E-钙粘附素(sE-钙粘附素)水平显著升高。然而，血清sE-钙粘附素水平在结直肠癌中的预后价值尚未得到证实。采集186例结直肠癌患者和21例健康志愿者的血清标本。采用酶联免疫吸附分析试剂盒检测血清sE-钙粘附素水平。我们研究了血清sE-钙粘附素水平与临床病理结果的关系。结直肠癌患者平均血清sE-钙粘附素水平显著高于对照组。平均sE-钙粘附素水平与肝转移、UICC分级和不良预后显著相关。血清sE-钙粘附素水平升高是预测预后不良的独立危险因素，也是预测肝转移的独立标志。在同期肝转移患者中，血清sE-钙粘附素水平升高的患者预后明显差于血清sE-钙粘附素水平较低的患者。结直肠癌患者术前sE-钙粘附素水平升高与预后不良有关。检测血清sE-钙粘附素水平可为预测肝转移瘤患者的预后提供有价值的信息。(C)2012 Elsevier Inc.保留所有权利。
Background. E-cadherin expression has been associated with an outcome in patients with colorectal cancer, and serum levels of soluble E-cadherin (sE-cadherin) are significantly elevated in patients with malignant disease. However, the prognostic value of serum sE-cadherin level has not been demonstrated in colorectal cancer.Methods. Serum samples were collected from 186 patients with colorectal cancer and 21 normal volunteers. Serum sE-cadherin levels were measured using an enzyme-linked immunosorbent assay kit. We investigated the relationship between serum sE-cadherin level and clinicopathologic findings.Results. Mean serum sE-cadherin levels were significantly higher in CRC patients than in controls. Mean sE-cadherin levels were significantly correlated with hepatic metastasis, UICC classification, and poor prognosis. Elevated serum sE-cadherin level was an independent risk factor for predicting poor prognosis, and was an independent marker for predicting hepatic metastasis. Among patients with synchronous hepatic metastases, the prognosis was significantly worse in patients with elevated serum sE-cadherin levels than in those with lower levels.Conclusions. Preoperative elevated sE-cadherin level is associated with poor prognosis in colorectal cancer. Measuring serum sE-cadherin may provide valuable information for predicting prognosis in patients with hepatic metastasis. (C) 2012 Elsevier Inc. All rights reserved.