Comparison of the Bone Forming Ability of Different Sized-alpha Tricalcium Phosphate Granules using a Critical Size Defect Model of the Mouse Calvaria
Comparison of the Bone Forming Ability of Different Sized-alpha Tricalcium Phosphate Granules using a Critical Size Defect Model of the Mouse Calvaria
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DOI：
10.11344/nano.7.63
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Tomoko Tokuda;Y. Honda;Y. Hashimoto;N. Matsumoto
中科院分区：
文献类型：
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作者：
Tomoko Tokuda;Y. Honda;Y. Hashimoto;N. Matsumoto
63引言由于严重牙周炎、创伤和损伤导致的骨缺损在牙科、颅面外科和骨科领域中常见。虽然自体骨移植仍然被认为是治疗的金标准，但该过程有几个缺点，例如需要二次手术和可收集骨的可用性有限[1]。人工骨移植被认为是有前途的替代自体骨移植。几种基于磷酸钙（CaP）的生物材料，如羟基磷灰石（HA）、磷酸三钙（TCP）和磷酸八钙（OCP），已被广泛研究用作人工骨，因为在适当的条件下，这些材料显示出优异的生物相容性和生物活性[2，3]。高温TCP，称为α-磷酸三钙（α-TCP），通常通过烧结具有适当组成的无定形前体来制备[4]。钙磷比理论上为1.50。通常，在中性pH条件下，β-TCP比OCP、β-TCP和HA更容易溶解[4]。此外，随着时间的推移，α-磷酸三钙在水溶液中转化为磷灰石[5]，以降低不同尺寸的α-磷酸三钙颗粒的骨形成能力的比较使用小鼠颅骨的临界尺寸缺损模型
63 Introduction Bone defects attributed to serious periodontitis, trauma, and injury are commonly encountered in the fields of dentistry, craniofacial surgery, and orthopedics. Although autogenous bone grafting is still considered the gold standard for treatment, this process has several drawbacks, such as the requirement of a second surgery and the limited availability of collectable bone [1]. Artificial bone grafts are thought to be promising alternatives to autogenous bone grafts. Several calcium phosphate (CaP)-based biomaterials, such as hydroxyapatite (HA), tricalcium phosphate (TCP), and octacalcium phosphate (OCP), have been intensively investigated for use as artificial bone because, under appropriate conditions, these materials show excellent biocompatibility and bioactivity [2, 3]. High-temperature TCP, known as alpha-tricalcium phosphate (-TCP), is often prepared by the sintering of amorphous precursors with the proper composition [4]. Its calciumto-phosphate ratio is theoretically 1.50. In general, -TCP dissolves more easily than OCP, -TCP, and HA under neutral pH conditions [4]. Furthermore, -TCP converts to apatite in aqueous solution over time [5], to lowComparison of the Bone Forming Ability of Different Sized-alpha Tricalcium Phosphate Granules using a Critical Size Defect Model of the Mouse Calvaria