INTRACELLULAR CALCIUM HOMEOSTASIS IN CARDIAC MYOCYTES
INTRACELLULAR CALCIUM HOMEOSTASIS IN CARDIAC MYOCYTES
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DOI：
10.1161/01.cir.87.6.1806
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发表时间：
1993-06-01
期刊：
影响因子：
37.8
通讯作者：
BRIDGE, JHB
中科院分区：
文献类型：
--
作者：
BARRY, WH;BRIDGE, JHB
心肌细胞的钙稳态是由膜电位调控的跨肌膜钙离子内流和外流途径的综合作用，以及以肌质网功能为主的细胞内钙摄取和释放的结果。这些过程可以在不同的疾病状态下被重要改变，也可以被药物改变，由此导致的收缩和舒张期[Ca~(2+)]i的变化可以导致心脏收缩和松弛的临床显著变化。可以预见，随着强大的分子和结构生物学工具被用于研究钙转运系统的调节，我们对心肌细胞内钙稳态的病理生理学的了解将会迅速增加。
Calcium homeostasis in cardiac myocytes results from the integrated function of transsarcolemmal Ca2+ influx and efflux pathways modulated by membrane potential and from intracellular Ca2+ uptake and release caused predominantly by SR function. These processes can be importantly altered in different disease states as well as by pharmacological agents, and the resulting changes in systolic and diastolic [Ca2+]i can cause clinically significant alterations in contraction and relaxation of the heart. It may be anticipated that a rapid increase in our understanding of the pathophysiology of Ca2+ homeostasis in cardiac myocytes will be forthcoming as the powerful new tools of molecular and structural biology are used to investigate the regulation of Ca2+ transport systems.