Characteristics of the increase in plasma brain natriuretic peptide level in left ventricular systolic dysfunction, associated with muscular dystrophy in comparison with idiopathic dilated cardiomyopathy
Characteristics of the increase in plasma brain natriuretic peptide level in left ventricular systolic dysfunction, associated with muscular dystrophy in comparison with idiopathic dilated cardiomyopathy
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DOI：
10.1016/j.nmd.2004.08.002
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发表时间：
2004-11-01
影响因子：
2.8
通讯作者：
Shirato, K
中科院分区：
文献类型：
--
作者：
Demachi, J;Kagaya, Y;Shirato, K
为了确定血浆脑钠肽水平是否在肌营养不良症和特发性扩张型心肌病中差异性升高，我们研究了左心室射血分数相似的患者的血浆脑钠肽水平和超声心动图参数。肌营养不良患者血浆脑钠肽水平较扩张型心肌病患者低，左室舒张末期内径较扩张型心肌病患者短。与原发性扩张型心肌病相比，肌营养不良患者血浆脑钠肽与左室射血分数的相关性下移。脑钠肽与左心室舒张末期内径之间的数据是重叠的，尽管肌营养不良患者的数据位于左心室舒张末期内径较短的一侧。血浆脑钠肽水平可能在两种具有相似左室收缩功能障碍的疾病中差异性升高。左心室扩张和体力活动的差异可能至少部分解释了不同的血浆脑钠肽水平。(C)2004 Elsevier B.V.保留所有权利。
To determine whether the plasma brain natriuretic peptide level increases differentially in muscular dystrophy and idiopathic dilated cardiomyopathy, we investigated the plasma brain natriuretic peptide level and echocardiographic parameters in patients with similarly low left ventricular ejection fraction. The plasma brain natriuretic peptide level was lower, and the left ventricular end-diastolic diameter was shorter in the patients with muscular dystrophy than in those with idiopathic dilated cardiomyopathy. The correlation between the plasma brain natriuretic peptide and left ventricular ejection fraction was shifted downward in the patients with muscular dystrophy compared with those with idiopathic dilated cardiomyopathy. Those between the brain natriuretic peptide and left ventricular end-diastolic diameter were superimposable, although the data from the muscular dystrophy patients were located at the shorter left ventricular end-diastolic diameter side. The plasma brain natriuretic peptide level may differentially increase in the two diseases with similar left ventricular systolic dysfunction. Differences in the left ventricular distension and in the physical activity might explain at least partially the different plasma brain natriuretic peptide levels. (C) 2004 Elsevier B.V. All rights reserved.