Risk factors for incident retinopathy in a diabetic and nondiabetic population - The Hoorn study
Risk factors for incident retinopathy in a diabetic and nondiabetic population - The Hoorn study
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DOI：
10.1001/archopht.121.2.245
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发表时间：
2003-02-01
影响因子：
--
通讯作者：
Polak, BCP
中科院分区：
文献类型：
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作者：
van Leiden, HA;Dekker, JM;Polak, BCP
目的：探讨糖化血红蛋白、年龄、性别、高血压、体质量指数、腰臀比、血脂水平、吸烟对糖代谢正常者和糖代谢异常者视网膜病变发生率的影响。方法：对233例50~74岁受试者进行眼底镜检和眼底照相检查，并进行平均9.4年的随访。通过优势比估计视网膜病变的相对风险，计算基线时心血管危险因素的三分位数。结果：糖代谢正常者、受损者和糖尿病者视网膜病变的累积发生率分别为7.3%、13.6%和17.5%。调整后的优势比分别为2.36(95%可信区间，1.02~5.49)和3.29(95%可信区间，1.11~9.72)和8.67(95%可信区间，1.85~40.60)。年龄、性别、体重指数、吸烟、血清甘油三酯、总高密度脂蛋白胆固醇和非高密度脂蛋白胆固醇水平与视网膜病变没有一致或统计学意义上的相关性(均为0.05)。结论：在普通人群中，血糖、高血压和腹型肥胖是视网膜病变的决定因素。
Objective: To investigate the effect of glycosylated hemoglobin, age, sex, hypertension, body mass index, waist-hip ratio, serum lipid levels, and smoking on the incidence of retinopathy in persons with normal and abnormal glucose metabolism.Methods: The incidence of retinopathy was determined in 233 individuals, aged 50 to 74 years, by ophthalmoscopy and fundus photography at baseline and after an average follow-up of 9.4 years. Relative risks for retinopathy, estimated by odds ratios, were calculated for tertiles of cardiovascular risk factors at baseline. Logistic regression analysis was used, without and with adjustment for age, sex, hypertension, and glucose metabolism.Results: The cumulative incidences of retinopathy among individuals with normal, impaired, and diabetic glucose metabolism were 7.3%, 13.6%, and 17.5%, respectively. Adjusted odds ratios for retinopathy were 2.36 (95% confidence interval, 1.02-5.49) for hypertension and 3.29 (95% confidence interval, 1.11-9.72) and 8.67 (95% confidence interval, 1.85-40.60) for the highest tertiles of glycosylated hemoglobin level and waist-hip ratio, respectively. No consistent or statistically significant associations with retinopathy were present for age, sex, body mass index, smoking, and serum levels of triglycerides and total, high-density lipoprotein, and non-high-density lipoprotein cholesterol (P>.05 for all).Conclusion: Glycemia, hypertension, and abdominal obesity are determinants for retinopathy in a general population.