Putative human liver progenitor cells in explanted liver
Putative human liver progenitor cells in explanted liver
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DOI：
10.1159/000106360
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Hodgson, H. J. F.
中科院分区：
文献类型：
--
作者：
Laurson, J.;Selden, C.;Hodgson, H. J. F.
背景/目的：肝细胞祖细胞经常从啮齿类动物中培养，但从人类肝脏中培养的报道很少。研究方法：培养从19个外植肝（在急性或慢性肝病的原位肝移植中取出）和组织学正常的人肝中分离的非实质细胞部分。结果：在培养2-3周后，可鉴定出增殖的上皮样集落，这是非常罕见的事件（
Background/Aims: Hepatocyte progenitors have frequently been cultured from rodents but reports from human liver are rare. Methods: Non-parenchymal cell fraction isolated from 19 explant livers ( removed at orthotopic liver transplantation for acute or chronic liver disease) and histologically normal human liver was cultured. Results: Proliferating epithelioid colonies were identifiable after 2-3 weeks culture as a very rare event (