Adenohypophysitis in rat pituitary allografts
Adenohypophysitis in rat pituitary allografts
复制标题
大鼠同种异体垂体移植物的腺垂体炎
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
K. Kovacs
中科院分区：
文献类型：
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作者：
F. Rotondo;A. Quintanar;Sylvia L. Asa;M. Lombardero;I. Bérczi;B. W. Scheithauer;É. Horváth;K. Kovacs
研究人员对移植到 Wistar 大鼠肾囊下的 81 例 Lewis 大鼠同种异体垂体移植物进行了组织学、免疫组织化学和超微结构的改变。还检查了带有同种异体移植物的大鼠的鞍内垂体。移植后的不同时间点处死受体大鼠。移植后两天，同种异体移植物的中央部分出现缺血性坏死。一周后，大量单核细胞浸润，主要由淋巴细胞组成，其次是巨噬细胞、浆细胞和粒细胞。移植后约三至四周，单核细胞浸润减少；幸存的腺垂体细胞，主要是催乳素（PRL）细胞，数量增加，坏死被结缔组织取代。在带有同种异体移植物的大鼠的鞍内垂体中没有观察到组织学变化。免疫组织化学证明存活的腺垂体细胞主要是产生PRL的细胞。电子显微镜显示腺垂体细胞破坏、一系列炎症细胞以及晚期成纤维细胞和胶原纤维的积累。 PRL 细胞是主要的细胞类型；他们的数量增加了。垂体同种异体移植物似乎是“外来的”，会引起免疫反应，这表明它们可以用作实验动物模型，用于形态学研究腺垂体炎的发生和进展，腺垂体炎是一种罕见的疾病，主要发生在年轻女性中，通常与怀孕有关。
The histological, immunohistochemical and ultrastructural alterations in 81 pituitary allografts from Lewis rats transplanted beneath the renal capsule of Wistar rats were investigated. Intrasellar pituitaries of rats bearing allografts were also examined. Recipient rats were sacrificed at various time points after transplantation. Two days after transplantation, the central portion of the allografts demonstrated ischaemic necrosis. A week later, massive mononuclear cell infiltrates consisting primarily of lymphocytes and to a lesser extent, macrophages, plasma cells and granulocytes became prominent. At about three to four weeks after transplantation, the mononuclear cell infiltrate diminished; the surviving adenohypophysial cells, mainly prolactin (PRL) cells, increased in number and necrosis was replaced by connective tissue. No histological changes were noted in the intrasellar pituitaries of rats bearing allografts. Immunohistochemistry demonstrated that the surviving adenohypophysial cells were mainly PRL‐producing cells. Electron microscopy revealed adenohypophysial cell destruction, a spectrum of inflammatory cells and, in late phase, accumulation of fibroblasts and collagen fibres. PRL cells were the prominent cell types; they increased in number. It appears that pituitary allografts are ‘foreign’ and evoke an immune response, suggesting that they may be used as an experimental animal model for morphological investigation of the development and progression of adenohypophysitis, a rare disease occurring mainly in young women often associated with pregnancy.
SJL 小鼠的自身免疫性垂体炎：来自新动物模型的临床见解。
影响因子：
4.8
作者：
Tzou,Shey-Cherng;Lupi,Isabella;Landek,Melissa;Gutenberg,Angelika;Tzou,Ywh-Min;Kimura,Hiroaki;Pinna,Giovanni;Rose,NoelR;Caturegli,Patrizio
通讯作者：
Caturegli,Patrizio